Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1982-09-23
1986-03-11
Wiseman, Thomas G.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 34, 435863, 435810, 436545, G10N 5300, C12Q 104, C12R 132, G01N 33534
Patent
active
045754845
ABSTRACT:
A method for detecting the presence of Mycobacteria in a fluid or tissue which comprises mixing the fluid or tissue containing a secretory product of Mycobacteria with a complex of a tracer-containing molecule and a binding macromolecule having reversible binding affinity for the tracer-containing molecule detecting the tracer-containing molecule, wherein the tracer-containing molecule is a charcoal-adsorbable protein from Mycobacterium tuberculosis which has a molecular weight of 20,000-30,000 and which is immunochemically stable from 4.degree. C. to 250.degree. C. and has a pH range from 3.0 to 9.0. The method is particularly applicable to the detection of infectious tuberculosis in humans and determining the antibiotic sensitivity of infecting Mycobacteria.
REFERENCES:
patent: 4118192 (1978-10-01), Sawai et al.
patent: 4205058 (1980-05-01), Wagner et al.
"Radioimmunoassay for Tuberculin Purified Protein Derivative", E. Straus and R. Yalow, Clinical Research, vol. 25, No. 3 A382 Ap 1977.
T. Daniel and P. Anderson Am. Rev. Resp. Dis., vol. 117, 1978, pp. 533-539.
K. Gupta and S. Landi, Can. J. Microbiology, vol. 24, No. 10, 1978, pp. 1242-1249.
Chemical Abstracts, vol. 88, 1978, Abstract 88:150381f.
Straus and Yalow, "Radioimmuno Assay for Tuberculin Purified Protein Derivative, Clinical Research, vol. 25, No. 3, A382, Apr. 1977.
Casella Anthony J.
Hespos Gerald E.
Huleatt Jayme A.
Montefiore Medical Center, Inc.
Wiseman Thomas G.
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