Binding assay for the detection of mycobacteria

Details Binding assay for the detection of mycobacteria Binding assay for the detection of mycobacteria

1982-09-23

1984-12-18

Wiseman, Thomas G.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 34, 435863, 436545, G01N 3354, C12Q 104

Patent

active

044891580

ABSTRACT:
A method for detecting the presence of Mycobacteria in a fluid or tissue which comprises mixing the fluid or tissue containing a secretory product of Mycobacteria with a complex of a tracer-containing molecule and a binding macromolecule having reversible binding affinity for the tracer-containing molecule and detecting the tracer-containing molecule, wherein the tracer-containing molecule is a charcoal-adsorbable protein from Mycobacterium tuberculosis which has a molecular weight of 20,000-30,000 and which is immunochemically stable from 4.degree. C. to 250.degree. C. and has a pH range from 3.0 to 9.0. The method is particularly applicable to the detection of infectious tuberculosis in humans and determining the antibiotic sensitivity of infecting Mycobacteria.

REFERENCES:
patent: 4205058 (1980-05-01), Wagner et al.
Straus and Yarlow, "Radioimmunoassay for Tuberculin Purified Protein Derivative," Clinical Research, vol. 25, No. 3, A382, Apr. 1977.
T. Daniel and P. Anderson Am. Rev. Resp. Dis. vol. 117, 1978 pp. 533-539.
K. Gupta and S. Landi, Can. J. Microbiology vol. 24, No. 10, 1978 pp. 1242-1249.
Chemical Abstracts, vol. 88, 1978, Abstract 88:150381f.

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