Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2005-06-30
2008-12-02
Ulm, John D (Department: 1649)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S007100, C435S007210, C436S501000
Reexamination Certificate
active
07459279
ABSTRACT:
The present invention relates to novel identified polynucleotides, polypeptides encoded by them and to the use of such- polynucleotides and polypeptides, and to their production. More particularly, the polynucleotides and polypeptides of the present invention relate to the G-protein coupled receptor family, referred to as G-family. The invention also relates to inhibiting or activating the action of such polynucleotides and polypeptides, to a vector containing said polynucleotides, a host cell containing such vector and transgenic animals where the IGS4-gene is either overexpressed, misexpressed, underexpressed or suppressed (knock-out animals). The invention further relates to a method for screening compounds capable to act as an agonist or an antagonist of said G-protein coupled receptor family IGS4. The invention also relates to the identification of the cognate ligand of the IGS4polypeptides of the invention. High affinity binding to said IGS4polypeptides is found for the neuropeptides known as neuromedin U.
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Berger Claudia
Deleersnijder Willy
Löken Christiane
Nys Guy
Venema Jakob
Finnegan Henderson Farabow Garrett & Dunner L.L.P.
Solvay Pharmaceuticals, Inc.
Ulm John D
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