Binding affinity of antigenic peptides for MHC molecules

Details Binding affinity of antigenic peptides for MHC molecules Binding affinity of antigenic peptides for MHC molecules

1996-04-30

1998-10-20

Cunningham, Thomas M.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Conjugate or complex

4241851, 4241931, A61K 3900

Patent

active

058243151

ABSTRACT:
This invention provides methods of improving the binding affinity of a peptide epitope for MHC Class II molecules by attaching to the N-terminus of the peptide epitope a hydrophobic amino acid or a peptide containing a hydrophobic amino acid. The invention also provides complexes between the modified antigenic peptides and MHC Class II molecules, as well as method for treating deleterious immune responses.

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