Bimatoprost crystalline form I

Details Bimatoprost crystalline form I Bimatoprost crystalline form I

2011-05-24

2011-05-24

Badio, Barbara P (Department: 1613)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

C564S171000, C549S214000

Reexamination Certificate

active

07947740

ABSTRACT:
The invention provides a novel polymorphic form I of crystalline bimatoprost, method for preparation thereof and new crystalline intermediates in the preparation. This form I of crystalline bimatoprost is used in purification of crude bimatoprost and in storage of bimatoprost as active pharmaceutical intermediate. Use of the physical form of bimatoprost in the manufacture of a medicament is also disclosed.

REFERENCES:
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patent: 2005/0209337 (2005-09-01), Gutman et al.
patent: 2008/0145403 (2008-06-01), Spada et al.
Morissette et al. High-throughput crystallization: polymorphs, salts, co-crystals and solvates of pharmaceutical solids. Adv. Drug Del. Rev. 56 (2004), 275-300.
Vippagunta et al. Crystalline solids. Adv. Drug. Del. Rev. 48 (2001), 3-26.
Easthope, et al (2002) “Topical Bimatoprost: A Review of its Use in Open-Angle Glaucoma and Ocular Hypertension.” Drugs Aging 19 (3) 231-248.

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