Bile acid derived steroidal dimers with novel amphiphilic...

Details Bile acid derived steroidal dimers with novel amphiphilic... Bile acid derived steroidal dimers with novel amphiphilic...

2007-06-26

2007-06-26

Badio, Barbara P. (Department: 1617)

Organic compounds -- part of the class 532-570 series

Organic compounds

Cyclopentanohydrophenanthrene ring system containing

Reexamination Certificate

active

10815109

ABSTRACT:
The need for new class of antifungal drugs with high efficacy, low toxicity and novel mode of action is well established. Synthesis and antifungal activity of bile acid derived new steroidal dimers N1,N3-Diethylenetriamine bis [cholic acid amide] (1) and N1,N3-Diethylenetriamine bis [deoxycholic acid amide] (2) having novel amphiphile topology is described.

REFERENCES:
patent: 5250524 (1993-10-01), Kramer et al.
Pandey et al., “Synthesis of a Head to Head Cholaphane”, Tetrahedron Letters, vol. 38(28), pp. 5045-5046, 1997.
Salunke et al., “New Steroidal Dimers with Antifugal and Antiproliferative Activity”, J. Med. Chem., vol. 47, pp. 1591-1594, 2004.

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