Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Cyclopentanohydrophenanthrene ring system doai
Reexamination Certificate
2005-07-19
2009-10-13
Badio, Barbara P (Department: 1612)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Cyclopentanohydrophenanthrene ring system doai
C552S548000, C552S549000
Reexamination Certificate
active
07601708
ABSTRACT:
This invention is directed to methods for providing sustained systemic concentrations of therapeutic or prophylactic agents such as GABA analogs following oral administration to animals. This invention is also directed to compounds and pharmaceutical compositions that are used in such methods.
REFERENCES:
patent: 3326758 (1967-06-01), Irmscher et al.
patent: 4024175 (1977-05-01), Satzinger
patent: 4508728 (1985-04-01), Nagai et al.
patent: 4560512 (1985-12-01), Firestone
patent: 4908353 (1990-03-01), Yamamoto
patent: 5094848 (1992-03-01), Brixner
patent: 5110797 (1992-05-01), Ienaga et al.
patent: 5462933 (1995-10-01), Kramer et al.
patent: 5541348 (1996-07-01), Arya et al.
patent: 5563175 (1996-10-01), Silverman
patent: 5646272 (1997-07-01), Kramer et al.
patent: 5668126 (1997-09-01), Kramer et al.
patent: 5684018 (1997-11-01), Alexander
patent: 6020370 (2000-02-01), Horwell
patent: 6028214 (2000-02-01), Silverman
patent: 6051683 (2000-04-01), Deigin et al.
patent: 6103932 (2000-08-01), Horwell
patent: 6117906 (2000-09-01), Silverman
patent: 6143738 (2000-11-01), Zasloff
patent: 6900192 (2005-05-01), Cundy et al.
patent: 6984634 (2006-01-01), Cundy et al.
patent: 6992076 (2006-01-01), Cundy et al.
patent: 7049305 (2006-05-01), Cundy et al.
patent: 7053076 (2006-05-01), Bhat et al.
patent: 7144877 (2006-12-01), Gallop et al.
patent: 0 272 462 (1998-06-01), None
patent: 285929 (1971-01-01), None
patent: WO92/09560 (1992-06-01), None
patent: WO93/23383 (1993-11-01), None
patent: WO97/29101 (1997-08-01), None
patent: WO97/33858 (1997-09-01), None
patent: WO97/33859 (1997-09-01), None
patent: WO98/17627 (1998-04-01), None
patent: WO99/08671 (1999-02-01), None
patent: WO99/21824 (1999-05-01), None
patent: WO99/31057 (1999-06-01), None
patent: WO99/31074 (1999-06-01), None
patent: WO99/31075 (1999-06-01), None
patent: WO99/61424 (1999-12-01), None
patent: WO00/15611 (2000-03-01), None
patent: WO00/23067 (2000-04-01), None
patent: WO00/31020 (2000-06-01), None
patent: WO00/50027 (2000-08-01), None
Moore et al., “Squalamine: An aminosterol antibiotic from the shark.” Proc. Natl. Acad. Sci., vol. 90, pp. 1354-1358, 1993.
Baringhaus, K.-H.; Matter, H.; Stengelin, S.; Kramer, W. Substrate specificity of the ileal and hepatic Na+/ bile acid contransporters of the rabbit. II. A reliable 3D QSAR pharmacophore model for the ileal Na+/ bile acid contransporter.J. Lipid Res.1999, 40, pp. 2158-2168.
Batta, et al.,J. Lipid Res., 1991, 32, pp. 977-983.
Bryans, J. S.; Wustrow, D. J. 3-Substituted GABA analogs with central nervous system activity: a review. Med. Res. Rev. 1999, 19, pp. 149-177.
Bundgaard, H. inDesign of Prodrugs(Bundgaard, H. Ed.), Elsevier Science B.V., 1985, pp. 1-92.
Ho, N. F. H. Utilizing bile acid carrier mechanisms to enhance liver and small instestine absorption.Ann. N. Y. Acad. Sci.1987, 507, pp. 315-329.
Jezyk, N.; Li, C.; Stewart, B. H.; Wu, X.; Bockbrader, H. N.; Fleisher, D. Transport of pregabalin in rat intestine and Caco-2 monolayers.Pharm. Res.1999, 16, pp. 519-526.
Kagedahl, M.; Swaan, P. W.; Redemann, C. T.; Tang, M.; Craik, C. S.; Szoka, F. C.; Oie, S. Use of the intestinal bile acid transporter for the uptake of cholic acid conjugates with HIV-1 protease inhibitory activity.Pharm. Res.1997, 14, pp. 176-180.
Kim, D.C., et al., Evaluation of bile acid transporter in enhancing intestinal permeability of renin-inhibitory peptides,J. Drug Targeting, 1993, 1, pp. 347-359.
Kramer, W.; Wess, G.; Schubert, G.; Bickel, M.; Girbig, F.; Gutjahr, U.; Kowalewski, S.; Baringhaus, K.-H.; Enhsen, A.; Glombik, H.; Mullner, S.; Neckermann, G.; Schulz, S.; Petzinger, E. Liver-specific drug targeting by coupling to bile acids.J. Biol. Chem.1992, 267, pp. 18598-18604.
Kramer, W.; Wess, G.; Neckermann, G.; Schubert, G.; Fink, J.; Girbig, F.; Gutjahr, U.; Kowalewski, S.; Baringhaus, K.-H.; Boger, G.; Enhsen, A.; Falk, E.; Friedrich, M.; Glombik, H.; Hoffmann, A.; Pittius, C.; Urmann, M. Intestinal absorption of peptides by coupling to bile acids.J. Biol. Chem.1994a, 269, pp. 10621-10627.
Kramer, w.; Wess, G.; Enhsen, A.; Bock, K.; Falk, E.; Hoffmann, A.; Neckerman, G.; Gantz, D.; Schulz, S.; Nickau, L.; Petzinger, E.; Turley, S.; Dietschy, J. M. Bile acid derived HMG-CoA reductase inhibitors.Biochim. Biophys. Acta1994b, 1227, pp. 137-154.
Kramer, W.; Stengelin, S.; Baringhaus, K.-H.; Enhsen, A.; Heuer, H.; Becker, W.; Corsiero, D.; Girbig, F.; Noll, R.; Weyland, C. Substrate specificity of the ileal and hepatic Na+/ bile acid cotransporters of the rabbit. I. Transport studies with membrane vesicles and cell lines expressing the cloned transporters.J. Lipid Res.1999, 40, pp. 1604-1617.
Kullak-Ublick, G. A.; Beuers, U.; Paumgartner, G. Hepatobiliary transport.J. Hepatology2000,32(Suppl. 1), pp. 3-18.
Navia, M. A.; Chaturvedi, P. R. Design principles for orally bioavailable drugs.Drug Discover Today1996, 1, pp. 179-189.
Petzinger, E.; Nickau, L.; Horz, J. A.; Schulz, S.; Wess, G.; Enhsen, A.; Falk, E.; Baringhaus, H.; K. Glombik, H.; Hoffmann, A.; Mullner, S.; Neckermann, G.; Kramer, W. Hepatobiliary transport of hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors conjugated with bile acids.,Hepatology1995, 22, pp. 1801-1811.
Swaan, P. W.; Szoka, F. C.; Oie, S. Use of the intestinal and hepatic bile acid transporters for drug delivery.Adv. Drug Delivery Rev.1996, 20, pp. 59-82.
Cundy Kenneth C.
Gallop Mark A.
Zhou Cindy X.
Badio Barbara P
Chang Lucy S.
Lambert William R.
Miller D. Byron
XenoPort, Inc.
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