Bile acid derivatives as FXR ligands for the prevention or...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Cyclopentanohydrophenanthrene ring system doai

Reexamination Certificate

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C552S554000

Reexamination Certificate

active

07858608

ABSTRACT:
The present invention relates to compounds of formula (I)wherein:R1is hydrogen or an alkyl group;R2is hydrogen or a halogen, nitro, alkyloxy, amino or carboxy group;Y is CH2, oxygen or sulfur;n is an integer from 1 to 4, and pharmaceutically acceptable salts, solvates or amino acid conjugates thereof for the treatment of FXR-mediated diseases or conditions.

REFERENCES:
Souillac, et al., Characterization of Delivery Systems, Differential Scanning Calorimetry, pp. 217-218 (in Encyclopedia of Controlled Drug Delivery, 1999, John Wiley & Sons, pp. 212-227).
Vippagunta et al. (Advanced Drug Delivery Reviews, 48 (2001), pp. 3-26).

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