Bilayers preparations

Details Bilayers preparations Bilayers preparations

1998-08-27

2000-02-08

Kishore, Gollamudi S.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

424401, 424427, 424430, 424434, 424436, A61K 9127

Patent

active

060225610

ABSTRACT:
A galactolipid material from wheat, produced by extraction of crushed wheat grains and subsequent chromatography of the extracted material, and having a content of DGDG of 51.5%, was mixed with the polar solvents, water and glycerol in order to test the swellability. The samples, prepared in glass tubes, were alternately mixed with a rod and centrifugated at room temperature until homogeneous. The samples were inspected as to physical appearance after storing for at least a week at room temperature.
Results:
20% (w/w) of galactolipid material in water gave a slightly yellow, highly viscous dispersion. Small liposomes could be observed in a polarizing microscope. At higher galactolipid concentrations a stiff gel was formed.
10% (w/w) of the same lipid material in anhydrous glycerol resulted in the formation of an opaque, highly viscous gel.

REFERENCES:
patent: 5151272 (1992-09-01), Engstrom
patent: 5234767 (1993-08-01), Wallach
patent: 5236709 (1993-08-01), Soma
patent: 5382430 (1995-01-01), Soma
Foley Chemical Abstracts 108, 200519, 1988.
Sprague Chemical Abstracts 100, 64424, 1983.

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