Biheterocyclic-9,11-trideoxy-PGF compounds

Details Biheterocyclic-9,11-trideoxy-PGF compounds Biheterocyclic-9,11-trideoxy-PGF compounds

1977-06-30

1978-09-05

Higel, Floyd D.

Harness for working animal

542453, 542468, 260140, 260141, 544131, 544137, 544140, 544360, 544368, 544371, 548369, 562471, 260295AM, 562472, 562465, 260307FA, 562503, 562463, 562464, 2603433R, 2603436, 260943, 260961, 424226, 424245, 424272, 424273R, 542414, 542417, 542420, 542423, 542424, 542427, 542439, 542440, 542447, C07D23104, C07D23106, C07D26102, C01B 1502

Patent

active

041122240

ABSTRACT:
The present specification; provides bicyclic nitrogen-containing 9,11,15-trideoxy-prostaglandin F analogs which are useful anti-inflammatory agents, anti-asthma agents, and platelet aggregation inhibitors, and a process for their preparation. Included are compounds of the following structural formulas: ##STR1## Especially described in the present specification are 9,11-trideoxy-9.alpha.,11.alpha.-azo-PGF-type; 9,11,15-trideoxy-11.alpha.,9.alpha.-epoxyimino-PGF-type; 9,11,15-trideoxy-9.alpha.,11.alpha.-epoxyimino-PGF-type; N,N'-dialkyl-9,11,15-trideoxy-9.alpha.11.alpha.-hydrazino-PGF-type; N,N'-bis(alkylcarbonyl)-9,11,15-trideoxy-9.alpha.,11.alpha.-hydrazino-PGF- type; N-alkyl-9,11,15-trideoxy-11.alpha.,9.alpha.-epoxyimino-PGF-type; N-(alkylcarbonyl)-9,11,15-trideoxy-11.alpha.,9.alpha.-epoxyimino-PGF-type; N-alkyl-9,11,15-trideoxy-9.alpha.,11.alpha.-epoxyimino-PGF-type; N-(alkylcarbonyl)-9,11,15-trideoxy-9.alpha.,11.alpha.-epoxyimino-PGF-type; 9,11,15-trideoxy-9.alpha.,11.alpha.-alkylhydrazino-PGF-type; 9,11,15-trideoxy-9.alpha.,11-.alpha.-(alkylcarbonyl)hydrazino-PGF-type; 9,11,15-trideoxy-11.alpha.,9.alpha.-alkylhydrazino-PGF-type; and 9,11,15-trideoxy-11.alpha.,9.alpha.-(alkylcarbonyl)-hydrazino-PGF-type compounds.

REFERENCES:
bundy et al, Chemical Abstracts, vol. 75, #48495r (1971).
Linke et al, Chemical Abstracts, vol. 78, #111275y (1973).
Heyman et al, Chemical Abstracts, vol. 79, #137071z (1973).
Corey et al, Proc. Nat. Acad. Sci. U.S.A., vol. 72, No. 9, pp. 3355 to 3358 (1975).
Bergstroem et al, Chemical Abstracts, vol. 66, #10640h (1967).
Struijk et al, Chemical Abstracts, vol. 66, #65151g (1967).
Pappo et al, Chemical Abstracts, vol. 75 #'s 48491m to 48494q (1971).

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