Biguanides and therapeutic compositions and uses of the same

Details Biguanides and therapeutic compositions and uses of the same Biguanides and therapeutic compositions and uses of the same

1976-01-06

1978-03-21

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

544137, 260268H, 26029387, 260307H, 42424854, 424250, 424267, A61K 3142, A61K 31535, A61K 31495, C07D26106

Patent

active

040804607

ABSTRACT:
The present invention relates to compounds having the general formula: ##STR1## in which R.sub.1 and R.sub.2, which may be the same or different, represent each a hydrogen atom, a C.sub.1 -C.sub.6 alkyl radical or a C.sub.3 -C.sub.6 cycloalkyl radical; R.sub.3 represents a hydrogen atom or a C.sub.1 -C.sub.4 alkyl radical; R.sub.4 and R.sub.5, which may be the same or different, represent a hydrogen atom a C.sub.1 -C.sub.6 alkyl radical or, together with the nitrogen atom to which they are attached, form a pyrrolidino, piperidino, morpholino or piperazinyl radical optionally substituted with a C.sub.1 -C.sub.4 alkyl radical, or a 4-hydroxypiperidino radical, and their pharmaceutically acceptable acid addition salts.
Said compounds are therapeutically useful for the control of the cardio-vascular system and of the blood pressure.

REFERENCES:
patent: 3808224 (1974-04-01), Aron-Samuel

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