Biguanide derivatives

Organic compounds -- part of the class 532-570 series – Organic compounds – Amino nitrogen containing

Reexamination Certificate

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C514S635000

Reexamination Certificate

active

10472229

ABSTRACT:
The present invention relates to biguanide derivatives of formula (I), wherein R1, R2, R3 and R4 have the meanings as given in claim (1). Compounds are useful in the treatment of pathologies associated with hyperglycaemia, such as diabetes.

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Hawley's Condensed Chemical Dictionary (14th Ed. 2002) (http://www. knovel.com/knovel2/Toc.jsp?BookID=704&VerticalID=0), “epimer”.
Shapiro et al., Hypoglycemic Agents. III. N-alkyl-and Aralkylbiguanides. Journal of the American Chemical Society (1959), vol. 81, pp. 3728-3736.
Wikipedia, the free encyclopedia (2006)(http://en.wikipedia.org/wiki/Stereoisomerism), pp. 1-3.
The Merck Index (11thEd. 1989), pp. 672, 1267, 1274, 1452.
John W. James et al., “The Synthesis of some heterocyclic derivatives of biguanide with antibacterial activity”, Journal of Medicinal Chemistry, vol. 11, No. 5, 1968, pp. 942-945.

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