Bifunctional urokinase variants with improved fibrinolytic chara

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

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435 697, 435212, 4353201, 424 9464, 536 232, 536 234, C12N 972, C12N 1558, C12N 1570, A61K 3848

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active

057472912

ABSTRACT:
Bifunctional urokinase variants possessing improved fibrinolytic properties and thrombin inhibitory activities, plasmids used in the production of these polypeptides, as well as thrombolytic agents containing one of the bifunctional urokinase variants as active ingredient are described.

REFERENCES:
patent: 4751180 (1988-06-01), Cousens et al.
patent: 5002887 (1991-03-01), Larsen
patent: 5188829 (1993-02-01), Kobayashi et al.
patent: 5256770 (1993-10-01), Glaser et al.
patent: 5328898 (1994-07-01), Greenberg
patent: 5376367 (1994-12-01), Williams
patent: 5434073 (1995-07-01), Dawson et al.
patent: 5571708 (1996-11-01), Yang et al.
Wun, T.C., et al., Journal of Biological Chemistry, vol. 268, "Isolation and characterization of urokinase from human plasma", pp. 3276-3283, 1982.
Steffens, et al., Hoppe-Seyler's Z. Physiolog. Chem., vol. 363, "The complete amino acid sequence of low molecular mass urokinase from human urine", pp. 1043-1058, 1982.
Heyneker, H., et al., Genetics of Industrial Microorganisms, "Expression of the human urokinase gene in E. coli ", pp. 214-221, 1982.
Lijnen, H., et al., Journal of Biological Chemistry, vol. 261, "Activation of plasminogen by pro-urokinase", pp. 1253-1258, 1986.
Stump, D., et al., Journal of Biological Chemistry, vol. 261, "Urokinase-related proteins in human urine", pp. 1267-1269, 1986.
Krstenansky, J., et al., Journal of Medicinal Chemistry, vol. 30, "Anticoagulant peptides", pp. 1688-1691, 1987.
Gardell, S., et al., Journal of Biological Chemistry, vol. 264, "Isolation, characterization and cDNA cloning of a vampire bat plasminogen activator", pp. 17947-17952, 1989.
Maraganore, J., et al., Biochemistry, vol. 29, "Design and characterization of hirulogs", pp. 7095-7101, 1990.
Rydel, T., et al., Reports, "The structure of a complex of recombinant hirudin and human .alpha.-thrombin", pp. 277-280, 1990.
Thien-Kai, H., et al., Nature, vol. 353, "Domains specifying thrombin-receptor interaction", pp. 674-677, 1991.
Robinson, J., et al., TIBTECH. vol. 9, "Redesigning t-PA for improved thrombolytic therapy", pp. 86-90, 1991.
Schneider, J., Thrombosis Research, vol. 64, "Heparin and the thrombin inhibitor", pp. 677-687, 1991.
Tebbe, U. et al., Z. Kardiol. vol. 80, Supplement 3, p. 32, 1991.
Lu, H., et al., Blood, vol. 78, "Comparative thrombolytic properties of bolus injections and continuous infusions of a chimeric anticoagulant", pp. 125-131, 1991.
Collen, D., et al., Blood, vol. 78, "Basic and clinical aspects of fibrinolysis and thrombolysis", pp. 3114-2124, 1991.
Collen, D., et al., Thrombosis and Haemostasis, vol. 65, "Thrombolytic and pharmacokinetic properties of human tissue-type plasminogen activator variants", pp. 174-180, 1991.
Lijnen, H. R., et al., Thrombosis and Haemostasis, vol. 66, "Strategies for the improvement of thrombolytic agents", pp. 88-110, 1991.
Fromage, N., et al., Fibrinolysis, vol. 5, "Synthesis, purification and biological properties of a truncated mutant form of human tissue plasminogen activator produced in E. coli ", pp. 187-190, 1991.
Gruber, A., et al., Circulation, vol. 84, "Antithrombotic effects of combining activated protein C and urokinase in nonhuman primates", pp. 2454-2462, 1991.
Eisenberg, P., Circulation, vol. 84, "Balance of procoagulant and fibrinolytic activity", pp. 2601-2603, 1991.
Vu, T.-K. H., et al., Cell, vol. 64, "Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation", pp. 1057-1068, 1991.
Flohe, R., Applied Microbiology and Biotechnology, vol. 36, "High expression vectors for the production of recombinant single-chain urinary plasminogen activatior from Escherichia coli ", pp. 640-649, 1992.
Yao, S.-K., et al., Journal of the American Physiological Society, "Thrombin inhibition enhances tissue-type plasminogen", pp. 374-379, 1992.
Yue, S.-Y., et al., Protein Engineering, vol. 5, "Characterization of the interactions of a bifunctional inhibitor", pp. 77-83, 1992.
Szczeklik, A., et al., Arteriosclerosis and Thrombosis, vol. 12, "Persistent generation of thrombin after acute myocardial infarction", pp. 548-553, 1992.
Mellott, M., et al., Arteriosclerosis and Thrombosis, vol. 12, "Vampire bat salivary plasminogen activator", pp. 212-221, 1992.
Gunzler, W., et al., Hoppe-Seyler's Z. Physiol. Chem., vol. 363, "The primary structure of high molecular mass urokinase from human urine", pp. 1155-1165, 1992.
German abstract of DE 41 37 996, 1993.
Strube, K. H., et al., Journal of Biological Chemistry, vol. 268, "Isolation, sequence analysis and cloning of haemadin", pp. 8590-8595, 1993.
H. Thien-Khai et al., Nature, Domains Specifying Thrombin-Receptor Interaction, vol. 353, pp. 674-677, (Oct. 17, 1991).
T.C. Wun, et al., J. of Biol. Chem., Isolation and Characterization of Urokinase From Human Plasma, vol. 257, No. 6, pp. 3276-3283, (Mar. 25, 1982).
K.H. Strube, et al., J. of Biol. Chem., Isolation, Sequence Analysis and Cloning of Haemadin, vol. 268, No. 12, pp. 8590-8595, (1993).
S.-K. Yao, et al., American Physiol. Soc., Thrombin Inhibition Enhances Tissue Type Plasminogen . . . , pp. 374-379, (1992).
S.-Y. Yue, et al., Protein Engineering, Characterization of the Interactions of a Bifunctional Inhibitor . . . , vol. 5, No. 1, pp. 77-83, (1992).
T. Rydel, et al., Reports, The Structure of a Complex of Recombinant Hirudin and Human .alpha.-Thrombin, pp. 277-280, (Jul. 1990).
J. Schneider, Thrombosis Research, Heparin and the Thrombin Inhibitor . . . , vol. 64, No. 9, pp. 677-687, (1991).
G. Steffens, et al., Hoppe-Seyler's Z. Physiol. Chem., The Complete Amino Acid Sequence of Low Molecular Mass Urokinase from Human Urine, Bd. 363, S. 1043-1058, (Sep. 1982).
D. Stump, et al., J. of Biol. Chem., Urokinase-Related Proteins in Human Urine, vol. 261, No. 3, pp. 1267-1269, (1986).
A. Szczeklik, et al., Arteriosclerosis and Thrombosis, Persistent Generation of Thrombin After Acute Myocardial Infarction: vol. 12, No. 5, pp. 548-553, (May 1992).
U. Tebbe, et al., Z. Kardiol. 80, Suppl. 3, 32-32 (1991).
M. Mellott, et al., Arteriosclerosis and Thrombosis, Vampire Bat Salivary Plasminogen . . . , vol. 12, No. 2, pp. 212-221, (Feb. 1992).
German Abstract, DE 41 37 996, (May 27, 1993).
S. Gardell, et al., J. of Biol. Chem., Isolation, Characterization and cDNA Cloning of a Vampire Bat . . . , vol. 264, No. 30, pp. 17947-17952, (1989).
A. Gruber, et al., Circulation, Antithrombotic Effects of Combining Activated Protein C and Urokinase in Nonhuman Primates, vol. 84, No. 6, pp. 2454-2462, (Dec. 1991).
P. Eisenberg, Circulation, Balance of Procoagulant and Fibrinolytic Activity, vol. 84, No. 6, pp. 2601-2603, (Dec. 1991).
R. Flohe, Appl. Microbiol. Biotechnol, High Expression Vectors for the Production of Recombinant Single-Chain Urinary Plasminogen Activator from Escherichia coli, vol. 36, pp. 640-649, (1992).
D. Collen, et al., Thrombosis and Haemostasis, Thrombolytic and Pharmacokinetic Properties of Human Tissue-Type Plasminogen Activator Variants . . . , vol. 6, No. 2, pp. 174-180, (1991).
D. Collen, et al., Blood, Basic and Clinical Aspects of Fibrinolysis and Thrombolysis, vol. 78, No. 12, pp. 3114-3124, (Dec. 15, 1991).
H.R. Lijnen, et al., Thrombosis and Haemostasis, Strategies for the Improvement of Thrombolytic Agents, vol. 66, No. 1, pp. 88-110 (1991).
J. Krstenansky, et al., J. Med. Chem., Anticoagulant Peptides: . . . , vol. 30, pp. 1688-1691, (1987).
H. Heyneker et al., Genetics of Industrial Microorganisms, Expression of Human Urokinase Gene in E. coli, pp. 214-221, (1982).
H. Lijnen, et al., J. of Biol. Chem., Activation of plasminogen by Pro-Urokinase, vol. 261, No. 3, pp. 1253-1258, (1986).
J. Maraganore, et al., Biochemistry, Design and Characterization of Hirulogs: . . . , vol. 29, pp. 7095-7101, (1990).
W. Gunzler, et al., Hoppe-Seyler's Z. Physiol. Chem., The Primary Structure of High Molecular Mass Urokinase from Human Urine, Bd. 363, S. 1155-1165, (Oct. 1992).
H. Lu, et al., Blood, Comparative Thrombolytic Properties of Bolus Injections and Continuous Infusions of a Chimeric . . . , vol. 78, No. 1, pp. 125-131, (Jul. 1, 1991).

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