Bifunctional oligosaccharides and also active compounds derived

Details Bifunctional oligosaccharides and also active compounds derived Bifunctional oligosaccharides and also active compounds derived

1988-06-03

1990-09-18

Griffin, Ronald W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536114, 435101, 435232, 43525231, 435835, C07H 100, C12N 988, C12N 120, C12N 100

Patent

active

049580167

ABSTRACT:
Bifunctional oligosaccharides, characterized by the formula ##STR1## wherein R.sub.1 represents a hydrogen atom, an alkyl group having 1-4 carbon atoms or an alkali metal, R.sub.2 represents a single bond or a divalent radical compound of monosaccharides and glc represents glucose, are obtained with the help of a specific microbial lyase cleaving the glucose-glucoronic acid bond in polysaccharides; said bifunctional oligosaccharides can be reacted with all kinds of products like proteins and drugs resulting in products having modified properties like solubility etc.

REFERENCES:
patent: 4607025 (1986-08-01), Petitou et al.
R. C. Caswell et al., "Detection of Alginate Lyases by Isoelectric Focusing and Activity Staining", International Journal of Biological Macromolecules, Structure Function and Interactions, vol. 8, No. 6, Dec. 1986, pp. 337-341, Butterworths & Co. (Publishers) Ltd.
P. E. Jansson et al., "Structural Studies of Gellan Gum, An Extracellular Polysaccharide Elaborated by Pseudomonas elodea", Carbohydrate Research, vol. 124, 1983, pp. 135-139, Elsevier Science Publishers B.V., Amsterdam, N.L.
R. I. Hollingsworth et al., "Bacteriophage-Induced Acidic Heteropolysaccharide Lyases that Convert the Acidic Heteropolysaccharides of Rhizobium Trifolii Into Oligosaccharide Units", Journal of Bacteriology, vol. 160, No. 2, Nov. 1984, pp. 510-516, American Society for Microbiology.
R. J. Linhardt et al., Review, Polysaccharide Lyases, Applied Biochemistry and Biotechnology, vol. 12, 1986, pp. 135-176, The Human Press, Inc.

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