Bifunctional nucleosides, oligomers thereof, and methods of maki

Details Bifunctional nucleosides, oligomers thereof, and methods of maki Bifunctional nucleosides, oligomers thereof, and methods of maki

1997-03-13

1999-04-06

Elliott, George C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 245, 536 253, 536 2781, 536 285, 536 2853, 536 2854, C07H 19067, C07H 19073, C07H 19167, C07H 19173

Patent

active

058920242

ABSTRACT:
Disclosed are novel bifunctional nucleoside analogs and oligonucleosides of 3-4 bases (trimers and tetramers) and longer containing at least two consecutive internucleoside linkages of two carbon-one nitrogen atom or two carbon-one oxygen atom (3'-NCC-5', 3'-CNC-5', 3'-OCC-5') internucleoside linkages. The bifunctional nucleosides are useful for preparing the trimers and tetramers, which, in turn, are useful, together with the nucleosides, in preparing oligonucleosides as well as chimeric oligonucleotide analogs, preferably antisense oligonucleosides and oligonucleotide analogs, of 6 to about 60 bases having at least two consecutive internucleoside linkages of two carbon atoms and one nitrogen atom or 2 carbon atoms and one oxygen atom in the oligonucleoside backbone.

REFERENCES:
patent: 4841039 (1989-06-01), Chu et al.
Baker et al. "An evaluation of certain chain-extended analogues . . . " J. Med. Chem. 26, 1530-1534, 1983.
Kurihara et al. "Improved synthesis of 5'-deoxy-5'-adenosineacetic acid" Chem. Pharm. Bull. 31, 2126-2129, 1983.
Lin et al. "Synthesis and biological activity of several amino analogues of thymidine" J. Med. Chem 21, 109-112, 1978.
Montgomery and Thomas. "Diazomethyl ketone derivatives of pyrimidine nucleosides" J. Org. Chem. 46, 594-598, 1981.
Montgomery et al. Analogs of 5'-deoxy-5'-(methylthio)adenosine. J. Med. Chem. 17:1197-1207, 1974.
Chu et al. Synthesis of Pyrimidine 3'-allyl-2', 3'-dideoxyribonucleosides by free radical coupling. J. Org. Chem. 54: 2767-2769, 1989.
Jones. Preparation of protected deoxyribonucleosides. In "Oligonucleotide Synthese" M. J. Gait, ed. IRL Press, Washington, DC. pp. 23-34, 1984.
Corey, D. R, et al. Generation of a catalytic sequence-specific hybrid DNase. Biochemistry 28(21): 8277-8286, 1989.
Garegg, P. J., et al. Nucleoside H-phosphonates. III. Chemical synthesis of oligodeoxynucleotides by the hydrogenphosphonate approach. Tetrahedron Letts. 27(34): 4051-4054, 1986.
Froehler, B. C., et al, Nucleoside H-phosphonates: Valuable intermediates in the synthesis of deoxyoligonucleotides. Tetrahedron Letts. 27(4): 469-472, 1986.
Chemical Abstracts, 111:78534g (1989).
Chemical Abstracts, 114:122934a (1991).
Chemical Abstracts, 78:148172p (1973).

Affiliated with

Also associated with

Rating

Bifunctional nucleosides, oligomers thereof, and methods of maki does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Bifunctional nucleosides, oligomers thereof, and methods of maki, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Bifunctional nucleosides, oligomers thereof, and methods of maki will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1372452