Bifunctional isothiocyanate derived thiocarbonyls as ligands for

Organic compounds -- part of the class 532-570 series – Organic compounds – Radioactive metal containing

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534 10, 530300, 5303915, 530408, 564 18, 564 23, 564 26, 564 27, 564 28, 556 45, 556 64, 556 81, 556110, 556118, 560 18, 562432, 536 266, 552502, 552504, C07C33706, C07C, C07D20744, C07D21371

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053268563

ABSTRACT:
This invention relates to chelating agents useful for coupling metal ions to biologically active molecules. In particular, isothiocyanate derived thiocarbonyls for chelating metals such as technetium are provided that can be conjugated to a targeting molecule such as an antibody, a peptide or a protein.

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