Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1990-12-07
1993-09-07
Wax, Robert A.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
435 696, 435 697, 435214, 4352523, 43525233, 4351723, 4353201, 530324, 530856, 930250, 536 234, 536 235, 536 231, C12P 2106, C12N 974, C12N 1500, A61K 3764
Patent
active
052428109
ABSTRACT:
The present invention relates to novel, bifunctional inhibitors of both platelet activation and thrombin. These bifunctional inhibitors are characterized by two domains -- a glycoprotein IIb/IIIa inhibitory domain and a thrombin inhibitory domain. The invention also relates to DNA sequences which encode the bifunctional inhibitors of this invention, recombinant DNA molecules which contain these DNA sequences and host transformed with these DNA molecules. The invention further relates to he recombinant expression of the bifunctional inhibitors of this invention by transformed hosts as well as to methods for purifying such recombinant bifunctional inhibitors. This invention also provides compositions and methods employing the novel bifunctional inhibitors alone or together with a fibrinolytic agent. Such compositions may be useful in patients for treating thrombotic disease, increasing reocclusion time, decreasing reperfusion time, simultaneously inhibiting thrombin- and platelet-mediated functions and inhibiting malignant cell growth.
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C. Ouyang et al.
Chao Betty H.
Maraganore John M.
Strauch Kathryn L.
Thompson Jeffrey S.
Biogen Inc.
Hendricks Keith D.
Marks Andrew S.
Miraglia Loretta A.
Pierri Margaret A.
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