Bifunctional DTPA-type ligand

Organic compounds -- part of the class 532-570 series – Organic compounds – Isothiocyanate esters

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

562434, 562435, 562443, 562450, C07C33128, C07C20506, C07C21144, C07C21165

Patent

active

054342872

ABSTRACT:
The subject matter of the present invention relates to bifunctional cyclohexyl DPTA ligands and methods for utilizing these compounds.

REFERENCES:
patent: 4339426 (1982-07-01), Meares et al.
patent: 4454106 (1984-06-01), Gansow et al.
patent: 4472509 (1984-09-01), Gansow et al.
patent: 4824986 (1989-04-01), Gansow
patent: 4831175 (1989-05-01), Gansow et al.
patent: 4849505 (1989-07-01), Stavrianopoulos
patent: 4881175 (1989-11-01), Ladner
Huneke et al., "Effective .alpha.-Particle-mediated Radioimmunotherapy of Murine Leukemia," Cancer Res., 52, 5818-5820 (1992).
McCall et al., "Simplified Method for Conjugating Macrocyclic Bifunctional Chelating Agents to Antibodies via 2-Iminothiolane," Bioconjugate Chem., 1(3), 222-226 (1990).
Mirzadeh et al., "Radiometal Labeling of Immunoproteins: Covalent Linkage of 2-(4-Isothiocyanatobenzyl)diethylenetriaminepentaacetic Acid Ligands to Immunoglobulin," Bioconjugate Chem., 1(1), 59.65 (1990).
Rodwell et al., "Site-specific Covalent Modification of Monoclonal Antibodies: In vitro and in vivo Evaluations," Proc. Natl. Acad. Sci. USA, 83, 2632-2636 (1986).
Waldmann, "Monoclonal Antibodies in Diagnosis and Therapy," Science, 252, 1657-1662 (1991).
Brechbiel et al., "Synthesis of 1-(.rho.-Isothiocyanatobenzyl) Derivatives of DTPA and EDTA. Antibody Labeling and Tumor-Imaging Studies," Inorganic Chemistry, 25: 2772-2781, Jul. 30, 1986.
Gansow et al., "Generator-Produced Bi-212 Chelated to Chemically Modified Monoclonal Antibody for Use in Radiotherapy," ACS Symposium Series 241, Chapter 15, Radionuclide Generators, 215-227. 1984.
Hnatowich et al., "DTPA-Coupled Antibodies Labeled wtih Yttrium-90," J. Nucl. Med., 26(5): 503-509. May 1985.
Hnatowich et al., "The Preparation and Labeling of DTPA-Coupled Albumin," Int. J. Appl. Radiat. Isot., 33: 327-332. 1982.
Khaw et al., "Myocardial Infarct Imaging of Antibodies to Canine Cardiac Myosin with Indium-111-Diethylenetriamine Pentaacetic Acid," Science, 209: 295-297. Jul. 1980.
Kozak et al., "Bismuth-212-labeled anti-Tac monoclonal antibody: .alpha.-Particle-emitting radionuclides as modalities for radioimmunotherapy," Proc. Natl. Aad. Sci. USA, 83: 474-478. Jan. 1986.
Kozak et al., "Nature of the Bifunctional Chelating Agent Used for Radioimmunotherapy with Yttrium-90 Monoclonal Antibodies: Critical Factors in Determining in Vivo Survival and Organ Toxicity," Cancer Research, 49: 2639-2644. May 15, 1989.
Kozak et al., "Radionculide-conjugated monoclonal antibodies: a synthesis of immunology, inorganic chemistry and nuclear science," Tibtech, 259-263. Oct. 1986.
Krejcarek et al., "Covalent Attachment of Chelating Groups to Macromolecules," Biochemical and Biophysical Research Communications, 77(2): 581-585. 1977.
Macklis et al., "Radioimmunotherapy with Alpha-Particle-Emtiting Immunoconjugates," Science, 240: 1024-1026. 1988.
Magerstadt et al., "Gd(DOTA): An Alternative to Gd(DTPA) as a T.sub.1,2 Relaxation Agent for NMR Imaging or Spectroscopy," Magnetic Resonance in Medicine, 3: 808-812. 1986.
Meares et al., "Conjugation of Antibodies with Bifunctional Chelating Agents: Isothiocyanate and Bromoacetamide Reagents, Methods of Analysis, and Subsequent Addition of Metal Ions," Analytical Biochemistry, 142: 68-78. 1984.
Morrison, "Genetically Engineered (Chimeric) Antibodies," Hospital Practice, 65-80. Oct. 15, 1989.
Paik et al., "Reduction of Background Activities by Introduction of a Diester Linkage Between Antibody and a Chelate in Radioimmunodetection of Tumor," J. Nucl. Med., 30(10): 1693-1701. Oct. 1989.
Rainsbury et al., "Tumor Localization With Monoclonal Antibody Radioactively Labelled with Metal Chelate Rather Than Iodine," The Lancet, 1347-1348. Dec. 11, 1982.
Scheinberg et al., "Tumor Imaging with Radioactive Metal Chelates Conjugated to Monoclonal Antibodies," Science, 215: 1511-1513. Mar. 19, 1982.
Spirlet et al., "Structural Characterization of a Terbium(III) Complex with 1,4,8,11-Tetraazacyclotetradecane-1,4,8,11-tetraacetic Acid. Lanthanide Ions and the Conformation of the 14-Membered Macrocycles," Inorg. Chem., 23: 4278-4283. 1984.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Bifunctional DTPA-type ligand does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Bifunctional DTPA-type ligand, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Bifunctional DTPA-type ligand will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2419474

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.