Bifunctional coupling agents and radionuclide labeled compositio

Details Bifunctional coupling agents and radionuclide labeled compositio Bifunctional coupling agents and radionuclide labeled compositio

1988-06-15

1993-06-08

Lee, Mary C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

558254, 564153, 564154, C07D20740, C07C32700

Patent

active

052181286

ABSTRACT:
A bifunctional coupling agent for joining a sulfhydryl-containing protein or peptide and a metallic radionuclide comprising a sulfhydryl selective electrophile, a chelator containing at least one protected thiol and a organic linking radical which serves to join said electrophile and said chelator is disclosed. A radiodiagnostic precursor comprising an antibody or antibody fragment and the specified bifunctional coupling agent bound to a sulfhydryl group on the antibody or antibody fragment is also disclosed.

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