Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – In an organic compound
Reexamination Certificate
2007-07-03
2007-07-03
Jones, D.L. (Department: 1618)
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
In an organic compound
C424S001110, C424S001810, C534S014000, C534S015000, C534S016000, C562S620000
Reexamination Certificate
active
10634335
ABSTRACT:
New types of hydroxamic acid-based bifunctional chelators are provided. These chelators are designed to chelate metal ions that can be detected either by their paramagnetic or radioactive properties. Conjugation with peptides or protein can be achieved by the presence of a linker moiety in the molecular structure of these chelators.
REFERENCES:
patent: 4256765 (1981-03-01), Munakata et al.
patent: 4741887 (1988-05-01), Coleman et al.
patent: 5539138 (1996-07-01), Flanagan et al.
patent: 5556939 (1996-09-01), Flanagan et al.
patent: 5632969 (1997-05-01), Flanagan et al.
patent: 5733342 (1998-03-01), Greindl et al.
patent: 5756825 (1998-05-01), Safavy et al.
patent: 92/20227 (1992-11-01), None
patent: 93/00082 (1993-01-01), None
patent: 94/05627 (1994-03-01), None
Altenburger, J.M., et al., “Useful hydroxylamine derivatives for the synthesis of hydroxamic acids,” Received in France Mar. 20, 1992, 5055-5058.
Atherton, E., et al., “Peptide synthesis. Part 10. Use of pentafluorophenyl esters of fluorenyl methoxycarbonylamino acids in solid phase peptide synthesis,”Tetra. Letts., 1998, 44(3), 843-857.
Bergeron, R,J., et. al., “Synthesis and biological evaluation of hydroxamate-based iron chelators,”J. Medicinal Chem., 1991, 34, 3182-3187.
Bergeron, R.J., et al., “The total synthesis of desferrioxamines E and G,”Tetrahedron, 1990, 46(17), 5581-5888.
Bergeron, R.J., et al., “The total synthesis of alcaligin,”J. Org. Chem., 1991, 56, 5560-5563.
Bergeron, R.J., et al., “The total synthesis of bisucaberin,”Tetrahedron, 1989, 45(16), 4939-4944.
Carpino, L.A., et al., “O-Acylhydroxylamines. I. Synthesis of O-Benzoylhydroxylamine,”J. Am. Chem. Soc., 81, 1959, 955-957.
Castro, J.L., et al., “Mitsunobu-like processes with a novel triphenylphosphine-cyclic sulfamide betaine,”J. Org. Chem., 1994, 59(9), 2289-2291.
Chaubet, F., et al., “The design of magnetic resonance contrast agents: new iron (III) dihydroxamate complexes,”Tetra. Letts., 1990, 31(40), 5729-5732.
Chaudhary, S.K., et al., “4-dimethylaminopyridine: an efficient and selective catalyst for the silyation of alcohols,”Pergamon Press Ltd., 1979, 20(2), 99-102.
Gibson, F.S., et al., “Selective removal of an N-BOC protecting group in the presence of a tert-butyl ester and other acid-sensitive groups,”J. Org. Chem., 1994, 59(11), 3216-3218.
Henry, J.R., et al., “Mitsunobu reactions of N-Alkyl and N-Acyl sulfonamides-an efficient route to protected amines,”Tetra. Letts., 1989, 30(42), 5709-5712.
Hou, Z., et al., “Preorganization of ferric alcaligin, Fe2L3. The first structure of a ferric dihydroxamate siderophore,”Am. Chem. Soc., 1996, 118(21), 5148-5149.
Huffman, W.F., et al., “Nuclear analogues of β-lactam antibiotics. 2. the total synthesis of 8-Oxo-4-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acids,”J. Am. Chem. Soc., 1977, 99.7, 3 pages.
Iida, H., et al., “An efficient, fully stereocontrolled total synthesis of N-Benzoyl-L-daunosamine,”J. Org. Chem., 1986, 51(22), 4245-4249.
Karunaratne, V., et al., “General method for the synthesis of trishydroxamic acids,”Tetra. Letts., 1992, 33(14), 1827-1830.
Katoh, A., et al., “N-hydroxy amides. Part 9. Synthesis and iron (III) complexes of tripodal hydroxamic acids derived from ω-(N-Hydroxyamino)alkanoic acids and tris-(2-aminoethyl)amine,”J. Chem. Soc. Perkin Trans., 1991, 1839-1842.
Koshti, N.M. et al., “Convenient method for the preparation of some polyhydroxamic acids: Michael addition of amines to acrylohydroxamic acid derivatives,”Tetra. Letts., 1994, 35(29), 5157-5160.
Lee, B.H., et al., “Natural ferric ionophores: Total synthesis of schizokinen, schizokinen A, and arthrobactin,”J. Org. Chem., 1983, 48(1), 24-31.
Miller, M.J., “Hydroxamate approach to the synthesis of β-lactam antibiotics,”Acc. Chem Res., 1986, 19, 49-56.
Nikam, S.S., et al., “Synthesis of hydroxamic acids: Pd/BaSO4as a new catalyst for the deprotection of o-benzyl hydroxamates,”Tetra. Letts., 1995, 36(2), 197-200.
Rajappa, S., et al., “Hydroxamic acids and their derivatives-III; Preparation of esters of pivalohydroxamic acid and their use in peptide synthesis,”Tetrahedron, 1967, 23, 4805-4809.
Ramalingam, K., et al., “Synthesis of nitroimidazole substituted 3,3,9,9-tetramethyl-4,8-diazaundecane-2,10-dione dioximes (propylene amine oximes, PnAOs): ligands for technetium-99m complexes with potential for imaging hypoxic tissue,”Tetrahedron, 1995, 51(10), 2875-2894.
Safavy, A., et al., “Synthesis of N-[tris[2-[[N-(benzyloxy)amino]carbonyl]ethyl]succinamic acid, trisuccin. Hydroxamic acid derivatives as a new class of bifunctional chelating agents,”Bioconjugate Chem., 1993, 4(3), 194-198.
Sandler, S.R., et al., “Chapter 12/Hydroxamic Acids,”Org. Functional Group Preparations, 1972, 3, 406-447.
Spanevello, R.A., et al., “synthesis of novel, highly potent cyclic-hexapeptide analogs of somatostatin. Potential application of orthogonal protection for affinity chromatography,”Tetra. Letts., 1991, 32(36), 4675-4678.
Still, W.C., et al., “Rapid chromatographic technique for preparative separations with moderate resolution,”J. Am. Chem. Soc., 1978, 43(14), 2923-2925.
Sun, Y., et al., “Synthesis and characterization of a new macrobicyclic (cryptand) siderophore containing three endocyclic hydroxamate donor groups,”Tetrahedron, 1990, 46(8), 2725-2736.
Wadsworth, D.H., “Azetidine,”Org. Syntheses Coll., 1988, vol. VI, 75-77.
DRAXIS Specialty Pharmaceuticals Inc.
Jones D.L.
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