Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant...
Patent
1988-01-04
1991-10-15
Russel, Jeffrey E.
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
424 9, 424 859, 424 93, 424 943, 530345, 530388, 530390, 530391, 530395, 530408, 530409, 530410, 435 792, 435174, 435177, 558 17, 514 6, 514 32, 514 42, 514 54, 514171, 536 11, 536 176, 536 22, 534 10, 534 15, 436501, 436504, A61K 4900, A61K 3944, C07K 1700, C12N 1100, C12Q 100, C12Q 125
Patent
active
050573020
ABSTRACT:
The present invention provides bifunctional chelating agents comprising a unique substrate reactive moiety incorporated into a carboxymethyl arm of a polyaminopolycarboxylate chelating framework capable of forming stable complexes with metal ions.
REFERENCES:
patent: 3994966 (1976-11-01), Sundberg et al.
patent: 4454106 (1984-06-01), Gansow et al.
patent: 4647447 (1987-03-01), Gries et al.
patent: 4678667 (1987-07-01), Meares et al.
patent: 4826673 (1989-05-01), Dean et al.
patent: 4831175 (1989-05-01), Gansow et al.
patent: 4885363 (1989-12-01), Tweedle et al.
Franz et al. (1987) Nucl. Med. Biol. 14(5):479-484.
Moi et al. (1987) Inorganic Chem. 26(21):3458-63.
Westerberg et al. (1989) J. Med. Chem. 32:236-3.
Altman et al., J. Chem. Soc. Perkin Trans. I., 365-368 (1983).
Altman et al., J. Chem. Soc. Perkin Trans. I., 59 (1984).
Borch et al., J. Amer. Chem. Soc., 93, 2897 (1971).
Brechbiel et al., Inorg. Chem., 25, 2772-81 (1986).
Buchsbaum et al., Int. J. Nucl. Med. Biol., vol. 12, No. 2, pp. 79-82, 1985.
Burnett et al., Biochem. Biophys. Res. Comm., 96, No. 1, 157-62 (1980).
Colcher et al., Cancer Res., 44, 5744 (1984).
DeRiemer et al., J. Med. Chem., 22, No. 9, 1019-23 (1979).
Goldenberg et al., N. Eng. J. Med., 298, 1384-88 (1978).
Goodwin et al., J. Nucl. Med., 22, No. 9, 787-92 (1981).
Green et al., Int. J. Nucl. Med. Biol., 12, No. 5, 381-86 (1985).
Haner et al., Arch. Biochem. Biophys., 231, No. 2, 477-86 (1984).
Hnatowich et al., J. Immunol. Meth., 65, 147 (1983).
Hwang and Wase, Biochim. Biophys. Acta, 512, 54-71 (1978).
Keenan et al., J. Nucl. Med., 25, 1197 (1984).
Kroll et al., Nature, 180, 919-20 (1957).
Laemmli et al., Nature, 227, 680 (1970).
Meares et al., J. Protein Chem., 3, No. 2, 215-228 (1984).
Meares et al., Anal. Biochem., 142, 68-78 (1984).
Moi et al., Anal. Biochem., 148, 249-253 (1985).
Morrison et al., Proc. Nat. Acad. Sci. U.S.A., 81, 6851-55 (1984).
Order et al., Int. J. Radiation Oncology Biol. Phys., 12, 277-81 (1986).
Paik et al., J. Nucl. Med., 24, No. 12, 1158 (1983).
Parham et al., J. Immunology, 131, 2895 (1983).
Porath and Olin, Biochemistry, 22, 1621-30 (1983).
Rosenberg et al., Biochemistry, 11, No. 19, 3623-28 (1972).
Schlom et al., Int. J. Cancer, 29, 539 (1982).
Schultz and Dervan, J. Amer. Chem. Soc., 105, 7748-50 (1983).
Sundberg et al., J. Med. Chem., 17, No. 12, 1304 (1974).
Takeshita and Maeda, Yukagaku, 19(10):984-93 (50-59) (1970).
Taliaferro et al., Inorg. Chem., 23, 1188-92 (1984).
Zalcberg and McKenzie, J. Clin. Oncology, vol. 3; pp. 876-881 (1985).
Zittle, Advan. Enzym., 12, 493, 513, 514, 520-22 (1951).
Johnson David K.
Kline Steven J.
Abbott Laboratories
Kim Kay
Russel Jeffrey E.
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