Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Reexamination Certificate
2006-05-16
2006-05-16
Le, Long V. (Department: 1641)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
C530S405000, C530S409000, C540S474000, C436S545000, C424S009360, C424S009364, C588S020000, C588S318000, C435S188000
Reexamination Certificate
active
07045606
ABSTRACT:
The invention concerns a ligand comprising (I) wherein n is an integer from 1 to 5 Y is CO2H or PO3H2T represents —X or -phenyl-X, wherein X represents NO2, NH2, NCS, NHCOCH2-Z, NHCO—W—COCNHS, —NH-Q, —NHCS-Q, —NHCOCH2-Q, or NHCO(CH2)m-Q where Q is a hapten chosen from the group consisting of steroids, enzymes, proteins, monoclonal antibodies, chimeric antibodies, or fragments thereof or any activated linker ready for coupling reaction, W is —(CH2)m- m is an integer from 1 to 10 Z is chloride, bromide or iodine
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Schumann, Herbert et al: “1,4,7,10,13,16,19,22-octaazacyclotetracosane-1,4,7,10,13,16,19,22-octaacetic acid (H8OTEC) and 1,4,7,10,14,17,20,23- octaazacyclohexacosane-1,4,7,10,14,17,20,23-octaacetic acid (H8OHEC). Synthesis and characterization of two large macrocyclic polyamine polycarboxylic ligands” Chem. Ber./Recl. (1997), 130 (2), 267-277, 1997, XP002199523 the whole document.
Ouadi A et al: “Synthesis of a novel bifunctional chelating agent for actinium complexation” Tetrahedron Letters, Elsevier Science Publishers, Amsterdam, NL, vol. 41, No. 37, Sep. 2000, pp. 7207-7209, XP004210234 ISSN: 0040-4039 cited in the application the whole document.
Apostolidis Christos
Gestin Jean-Francois
Ouadi Ali
European Community
Haq Shafiqul
Le Long V.
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