Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2006-10-03
2006-10-03
Solola, Taofiq (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C549S404000, C549S405000, C549S408000
Reexamination Certificate
active
07115657
ABSTRACT:
The present invention relates to novel bifunctional agents possessing antioxidant and antiarrhytmic activity, methods for the synthesis of the same and their applications in treating ischemia-reperfusion injury, as well as a variety of disorders related to free radicals and/or arrhythmias. These bifunctional drugs should preferentially segregate in the membrane and produce their antiarrhytmic effects while, at the same time, help in protecting the membrane lipids by scavenging free radicals. The present invention comprises compounds represented by Formula (I), wherein R1, R2, R3, R4, R5are further defined
REFERENCES:
patent: 0 293 078 (1988-11-01), None
P. J. Silver et al, “Low Molecular Weight Analogs of Trolox with Potent Antioxidant Activity in Vitro and In Vivo,” Chemical Abstracts, vol. 117, No. 1, p. 19, 1992, Columbus, Ohio, US, XP-002163993.
Calogeropoulou Theodora
Koufaki Maria
Makriyannis Alexandros
Finnegan Henderson Farabow Garrett & Dunner LLP
Solola Taofiq
Uni-Pharma Kleon Tsetis Pharmaceutical Laboratories S.A.
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