Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1997-08-26
2000-09-19
Raymond, Richard L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514315, 514183, 546 1, 546184, C07D20736, C07D21316, A61K 31395
Patent
active
061212725
ABSTRACT:
The invention provides compounds which are useful as inhibitors of metalloproteases, and which are effective in treating conditions characterized by excess activity of these enzymes. In particular, the present invention relates to a compound having a structure according to Formula (I) ##STR1## as described in the claims, or an optical isomer, diastereomer or enantiomer thereof, or a pharmaceutically-acceptable salt, or biohydrolyzable alkoxyamide, ester, acyloxyamide, or imide thereof. Also disclosed are compounds, pharmaceutical compositions and methods of treating diseases characterized by metalloprotease activity using these compounds or the pharmaceutical compositions containing them.
REFERENCES:
patent: 3501489 (1970-03-01), Wei et al.
patent: 4595700 (1986-06-01), Donals et al.
patent: 4695575 (1987-09-01), Janssens et al.
Iida, T., et al., "New Asymmetric Reactions Using a Gallium Complex: A Highly Enantioselective Ring Opening of Epoxides with Thiols Catalyzed by a Callium.cntdot.Lithium.cntdot.bis(binaphth oxide) Complex", J. Am. Chem. Soc. (1997), vol. 119, pp. 4783-4784.
Coldham, I., et al., "synthesis of cyclic amines and allylic sulfides by phenylthio migration of .beta.-hydroxy sulfides", J. Chem. Soc., Perkin Trans. 1, (1993), 14, pp. 1637-1656.
Kaszubska, J., et al., "Synthesis of derivatives of 2-[2-(arylthio)ethyl]pyrrolidine", Pol. J. Chem., (1982), vol. 56, pp. 1543-1547.
Nakagawa, M., et al., "Efficient Michael addition reactions of the N-(arylsulfonyl)-3-phenylthiopiperidones. Synthesis of 3-substituted dihydropyridinones", Chemical Abstracts, vol. 120, No. 9 (Feb. 28, 1994), Abstract No. 106714.
Verbiscar, A. J., et al., "Synthesis of cis- and trans-4-mercapto-L-proline derivatives", Chemical Abstracts, vol. 073, No. 5 (Aug. 5, 1970), Abstract No. 025845.
Ohtani, M., et al., "Preparation of pyrrolidine derivatives as phospholipase A2 inhibitors", Chemical Abstracts, vol. 126, No. 17 (Apr. 28, 1997), Abstract No. 225294.
Tanner, D., et al., "Total synthesis of balanol. Part 2. Completion of the synthesis and investigation of the structure and reactivity of two key heterocyclic intermediates", Chemical Abstracts, vol. 126, No. 21 (May 26, 1997), Abstract No. 277320.
Beszant, B., et al. "Synthesis of Novel Modified Dipeptide Inhibitors of Human Collagenase: beta-Mercapto Carboxylic Acid Derivatives", Journal of medicinal Chemistry, vol. 36 (1993), pp. 4030-4039.
Chapman, K.T., et al., "Inhibition of Matrix Metalloproteinases by N-Carboxyalkyl Peptides", Journal of Medicinal Chemistry, vol. 36 (1993), pp. 4293-4301.
Johnson, w.K., Roberts, N.a., and Borkakoti, N., "Collagenase Inhibitors: Their Design and Potential Therapeutic Use", Journal of Enzyme Inhibition, vol. 2 (1987), pp. 1-22.
Schwartz, M.a., Van Wart, H.E., "synthetic Inhibitors of Bacterial and Mammalian Interstitial Collagenases", Progress in Medicinal chemistry, vol. 29 (1992), p. 271.
Suh, J., Lee, S.H., Uh, J.Y., "Zn (II)--Chelating Inhibitors of Carboxypeptidase A", Bioorganic & Medicinal Chemistry Letters, vol. 5 (1995), pp. 585-588.
Turbanti, L., et al., "1,2-Cyclomethylenecarboxylic Monoamide Hydroxamic Derivatives. A Novel Class of Non-amino Acid Angiotensin Converting Enzyme Inhibitors", Journal of Medicinal Chemistry, vol. 36 (1993), pp. 699-707.
Almstead Neil Gregory
Bradley Rimma Sandler
De Biswanath
Garrett Garry Steven
Marlin, II John Emory
Raymond Richard L.
Roof Carl J.
Sripada Pavanaram K
Suter David L.
The Procter & Gamble & Company
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