Bicyclopolyazamacrocyclophosphonic acid half esters

Details Bicyclopolyazamacrocyclophosphonic acid half esters Bicyclopolyazamacrocyclophosphonic acid half esters

1996-07-15

1998-05-12

Kight, John

Organic compounds -- part of the class 532-570 series

Organic compounds

Radioactive metal containing

534 14, 424 111, C07F 1300

Patent

active

057506604

ABSTRACT:
Bicyclopolyazamacrocyclophosphonic acid compounds are disclosed which may form inert complexes with Gd, Mn or Fe ions. The overall charge of the complex can be varied to alter the in vivo biolocalization. Such complexes can be covalently attached to an antibody, antibody fragment or other biologically active molecule to form conjugates. The complexes and conjugates are useful as contrast agents for diagnostic purposes.

REFERENCES:
patent: 4156683 (1979-05-01), Lehn
patent: 4639365 (1987-01-01), Sherry
patent: 4647447 (1987-03-01), Gries et al.
patent: 4822594 (1989-04-01), Gibby
patent: 4877600 (1989-10-01), Bonnemain et al.
patent: 4885363 (1989-12-01), Tweedle et al.
patent: 4889931 (1989-12-01), Rocklage et al.
patent: 4920195 (1990-04-01), Kankare et al.
patent: 4923985 (1990-05-01), Gansow et al.
patent: 4940796 (1990-07-01), Mathias et al.
patent: 4957939 (1990-09-01), Gries et al.
patent: 4963344 (1990-10-01), Gries et al.
patent: 4986980 (1991-01-01), Jacobsen
patent: 5026802 (1991-06-01), Mathias et al.
patent: 5047527 (1991-09-01), Handel et al.
patent: 5049667 (1991-09-01), Schaefer et al.
patent: 5053503 (1991-10-01), Dean et al.
patent: 5059412 (1991-10-01), Simon et al.
patent: 5236695 (1993-08-01), Winchell et al.
patent: 5318772 (1994-06-01), Frank et al.
patent: 5320829 (1994-06-01), Garlich et al.
patent: 5322681 (1994-06-01), Klaveness
patent: 5334371 (1994-08-01), Gries et al.
patent: 5385893 (1995-01-01), Kiefer
patent: 5428139 (1995-06-01), Kiefer et al.
patent: 5480990 (1996-01-01), Kiefer et al.
patent: 5645818 (1997-07-01), Jackels et al.
Greene, Protective Groups in Organic Synthesis, John Wiley & Sons, pp. 10-17, 1981.
Chemical Abstracts, vol. 113, (1990), p. 701, Abstract No. 59139g.
Chemical Abstracts, vol. 115, (1991), p. 21, Abstract No. 280870b.
Chemical Abstracts, vol. 115, (1991), p, 585, Abstract No. 58294h.
Chemical Abstracts, vol. 115, (1991), p. 845, Abstract No. 20829y.
Chemical Abstracts, vol. 115, (1991), p. 938, Abstract No. 183387s.
Chemical Abstracts, vol. 116, (1992), p. 583, Abstract No. 21083h.
Derwent Publications. Ltd., Abstract No. 85-018012/03. Mar. 25, 1983.
Derwent Publications, Ltd., Abstract No. 87-229593/33, Jan. 23, 1986.
Derwent Publications, Ltd., Abstract No. 87-250202/35, Feb. 13, 1986.
Derwent Publications, Ltd., Abstract No. 90-099224/13, Aug. 24, 1988.
Derwent Publications, Ltd., Abstract No. 90-307139/41, Mar. 24, 1989.
Derwent Publications, Ltd., Abstract No. 91-216892/30, Jan. 18, 1990.
Chemical Abstracts, vol. 74, (1974), p. 476, Abstract No. 60361f.
Chemical Abstracts, vol. 95, (1981), p. 702, Abstract No. 115487t.
Chemical Abstracts, vol. 100, (1984), p. 593, Abstract No. 209772f.
Chemical Abstracts, vol. 109, (1988), pp. 839, Abstract No. 242975h.
Chemical Abstracts, vol. 110, (1989), p. 892, Abstract No. 127400a.
Chemical Abstracts, vol. 111, (1989), p. 921, Abstract No. 208180b.
Derwent Abstracts, No. 91-187135/26 for EP 434345.
Derwent Abstracts, No. 91-187136/26 for EP 434346.
Derwent Abstracts, No. 91-283191/39 for EP 448191.
Derwent Abstracts, No. 91-304859/42 for EP 451824.
Derwent Abstracts, No. 91-319187/44 for EP 454078.
On Line Ref. From IFI Claims Database for US 5,049,667, dated Sep. 17, 1991 .

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