Bicyclopolyazamacrocyclophosphonic acid complexes for use as rad

Details Bicyclopolyazamacrocyclophosphonic acid complexes for use as rad Bicyclopolyazamacrocyclophosphonic acid complexes for use as rad

1991-12-10

1995-06-27

Tucker, Philip

Organic compounds -- part of the class 532-570 series

Organic compounds

Radioactive metal containing

534 14, C07F 1300

Patent

active

054281393

ABSTRACT:
Complexes of bicyclopolyazamacrocyclophosphonic acid compounds with a metal ion, e.g. .sup.153 Sm, .sup.177 Lu, .sup.159 Gd, .sup.149 Pm, .sup.140 La, .sup.175 Yb, .sup.166 Ho, .sup.90 Y, .sup.47 Sc, .sup.186 Re, .sup.188 Re, .sup.142 Pr, .sup.99m Tc, .sup.67 Ga, .sup.68 Ga, .sup.105 Rh, .sup.97 Ru, .sup.111 In, .sup.113m In or .sup.115m In ion, are disclosed. The complexes can be covalently attached to a biologically active molecule, e.g. an antibody or antibody fragment, to form conjugates. The complexes and conjugates are useful as radiopharmaceutical agents for therapy and/or diagnostic purposes.

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