Organic compounds -- part of the class 532-570 series – Organic compounds – Rare earth containing
Patent
1994-08-03
1998-04-14
Hollinden, Gary E.
Organic compounds -- part of the class 532-570 series
Organic compounds
Rare earth containing
534 16, 556 15, 556 16, 556 50, 424 9363, C07F 500, C07F 1300, C07F 1500, A61K 4900
Patent
active
057392943
ABSTRACT:
Bicyclopolyazamacrocyclophosphonic acid compounds are disclosed which may form inert complexes with Gd, Mn or Fe ions. The overall charge of the complex can be varied to alter the in vivo biolocalization. Such complexes can be covalently attached to an antibody, antibody fragment or other biologically active molecule to form conjugates. The complexes and conjugates are useful as contrast agents for diagnostic purposes.
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Garlich Joseph R.
Kiefer Garry E.
Simon Jaime
Hollinden Gary E.
Kelley Lara C.
Kimble Karen L.
The Dow Chemical Company
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