Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acids and salts thereof
Patent
1991-08-26
1993-03-30
Dees, Jose G.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carboxylic acids and salts thereof
556 21, 556136, 556146, C07C 6304, C07F 1500, C07F 1502
Patent
active
051985764
ABSTRACT:
Bicyclooctyl phosphines are disclosed having the formula: ##STR1## where R is C.sub.1 to C.sub.6 linear or branched alkyl, phenyl, substituted phenyl, halo, or C.sub.1 or C.sub.6 alkoxy; Ar is phenyl, substituted phenyl, naphthyl or substituted naphthyl; and x is 0 or 1.
These phosphines are treated with ruthenium compounds to form a complex of the formula Ru.sub.x H.sub.y Cl.sub.z (anthraphos-m).sub.2 (S).sub.p, where S is a tertiary amine; and when y is 0, then x is 2, z is 4 and p is 1; and when y is 1, then x is 1, z is 1 and p is 0; where anthraphos-m is: ##STR2## where R is C.sub.1 to C.sub.6 linear or branched alkyl, phenyl, substituted phenyl, C.sub.1 to C.sub.6 linear or branched alkoxy or halo; Ar is phenyl or substituted phenyl or naphthyl or substituted naphthyl; and m is 0 or 1.
The complex is useful in a process for the asymmetric reduction of olefinic carboxylic acids of the formula: ##STR3## where R.sub.1 and R.sub.2 are the same or different and are hydrogen, alkyl, cycloalkyl or haloalkyl; and Ar' is aryl or substituted aryl.
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Conrad, III Joseph M.
Dees Jos,e G.
Ethyl Corporation
Hammond Richard J.
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