Bicyclonucleoside analogues

Details Bicyclonucleoside analogues Bicyclonucleoside analogues

2011-08-09

2011-08-09

McIntosh, III, Traviss C (Department: 1623)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C536S023100

Reexamination Certificate

active

07994145

ABSTRACT:
Oligonucleotide analogues which have anti-sense or anti-gene activity, as well as in vivo stability, or pharmaceutically acceptable salts thereof. The oligonucleotide analogues have one or more structural units represented by the following formula (1a):provided that when the oligonucleotide has two or more structural units of formula (1a), each B is the same or different, wherein B represents a purin-9-yl group or a 2-oxo-1,2-dihydropyrimidin-1-yl group.

REFERENCES:
patent: 3687808 (1972-08-01), Merigan, Jr. et al.
patent: 4689320 (1987-08-01), Kaji
patent: 4806463 (1989-02-01), Goodchild et al.
patent: 5004810 (1991-04-01), Draper
patent: 5166195 (1992-11-01), Ecker
patent: 5194428 (1993-03-01), Agrawal et al.
patent: 5242906 (1993-09-01), Pagano et al.
patent: 5248670 (1993-09-01), Draper et al.
patent: 5442049 (1995-08-01), Anderson et al.
patent: 5457189 (1995-10-01), Crooke et al.
patent: 5514577 (1996-05-01), Draper et al.
patent: 5523389 (1996-06-01), Ecker et al.
patent: 5580767 (1996-12-01), Cowsert et al.
patent: 5582972 (1996-12-01), Lima et al.
patent: 5582986 (1996-12-01), Monia et al.
patent: 5591600 (1997-01-01), Ecker
patent: 5591623 (1997-01-01), Bennett et al.
patent: 5591720 (1997-01-01), Anderson et al.
patent: 5607923 (1997-03-01), Cook et al.
patent: 5620963 (1997-04-01), Cook et al.
patent: 5658891 (1997-08-01), Draper et al.
patent: 5661134 (1997-08-01), Cook et al.
patent: 5681747 (1997-10-01), Boggs et al.
patent: 5681944 (1997-10-01), Crooke et al.
patent: 5684143 (1997-11-01), Gryaznov et al.
patent: 5691461 (1997-11-01), Ecker et al.
patent: 5877309 (1999-03-01), McKay et al.
patent: 5955443 (1999-09-01), Bennett et al.
patent: 5985558 (1999-11-01), Dean et al.
patent: 6111094 (2000-08-01), Bennett et al.
patent: 6127533 (2000-10-01), Cook et al.
patent: 6268490 (2001-07-01), Imanishi et al.
patent: 6670461 (2003-12-01), Wengel et al.
patent: 6794499 (2004-09-01), Wengel et al.
patent: 7034133 (2006-04-01), Wengel et al.
patent: 7314923 (2008-01-01), Kaneko et al.
patent: 7335765 (2008-02-01), Kaneko et al.
patent: 7816333 (2010-10-01), Kaneko et al.
patent: 2002/0147332 (2002-10-01), Kaneko et al.
patent: 2003/0134808 (2003-07-01), Wengel et al.
patent: 2003/0144231 (2003-07-01), Wengel et al.
patent: 2003/0207841 (2003-11-01), Kaneko et al.
patent: 2005/0287566 (2005-12-01), Wengel et al.
patent: WO 94/08003 (1994-04-01), None
patent: WO 96/31557 (1996-10-01), None
patent: WO 98-39352 (1998-09-01), None
patent: WO 99/14226 (1999-03-01), None
Griffiths and Nickoloff, “Keratinocyte Intercellular Adhesion Molecule-1 (ICAM-1) Expression Precedes Dermal T Lymphocytic Infiltration in Allergic Contact Dermatitis (Rhus dermatitis)”,Am. J. Pathology, 1989, 135, 1045-1053.
Thuong and Helene, “Sequence-Specific Recognition and Modification of Double-Helical DNA by Oligonucleotides”,Angew. Chem. Int. Ed. Engl., 1993, 32, 666-690.
Englisch and Gauss, “Chemically Modified Oligonucleotides as Probes and Inhibitors”,Angewandte Chemie, International Edition, 1991, 30, 613-722.
Manoharan et al., “Chemical Modifications to Improve Uptake and Bioavailability of Antisense Oligonucleotides”,Ann. N.Y. Acad. Sci., 1992, 660, 306-309.
Stetler-Stevenson et al., “Tumor Cell Interactions with the Extracellular Matrix During Invasion and Metastasis”,Annu. Rev. Cell Biol., 1993, 9, 541-573.
Cook, “Medicinal chemistry of antisense oligonucleotides—future opportunities”,Anti-Cancer Drug Design, 1991, 6, 585-607.
Morassutti et al., “Reduction ofmdr1Gene Amplification in Human Multidrug-Resistant LoVo DX Cell Line Is Promoted by Triple Helix-Forming Oligonucleotides”,Antisense&Nucleic Acid Drug Development, 1999, 9, 261-270.
Sanghvi, “Heterocyclic Base Modifications in Nucleic Acids and their Applications in Antisense Oligonucleotides”,Antisense Research and Applications, Ed. S.T. Crooke and B. Lebleu, CRC Press, 1993, 273-288 (Chapter 15).
Shiohara et al., “Fixed Drug Eruption”,Arch. Dermatol., 1989, 125, 1371-1412.
Ebbinghaus et al., “Inhibition of Transcription Elongation in the HER-2
eu Coding Sequence by Triplex-Directed Covalent Modification of the Template Strand”,Biochemistry, 1999, 38, 619-628.
Catapano et al., “Inhibition of Gene Expression and Cell Proliferation by Triple Helix-Forming Oligonucleotides Directed to thec-mycGene”,Biochemistry, 2000, 39, 5126-5138.
Mishra et al., “Improved leishmanicidal effect of phosphorotioate antisense oligonucleiotides by LDL-mediated delivery”,Biochimica et Biophysica Acta, 1995, 1264, 229-237.
Svinarchuk et al., “Inhibition of HIV proliferation in MT-4 cells by antisense oligonucleotide conjugated to lipophilic groups”,Biochimie, 1993, 75, 49-54.
Manoharan et al., “Introduction of a lipophilic thioether tether in the minor groove of nucleic acids for antisense applications”,Bioorganic&Medicinal Chemistry Letters, 1993, 3, 2765-2770.
Manoharan et al., “Cholic Acid-Oligonucleotide Conjugates for Antisense Applications”,Bioorganic&Medicinal Chemistry Letters, 1994, 4, 1053-1060.
Yu et al., “Specific Inhibition of PCR by Non-Extendable Oligonucleotides Using a 5′ to 3′ Exonuclease-Deficient DNA Polymerase”,Biotechniques, 1997, 23, 714-720.
Lisby et al., “Intercellular adhesion molecule-I (ICAM-I) expression correlated to inflammation”,Brit. J. Dermatol., 1989, 120, 479-484.
Tam and Fraser-Reid, “A synthetic route to 4-C-methyl-xylo-furanose”,Can. J. Chem., 1979, 57, 2818-2822.
Resnicoff et al., “Inhibition of rat C6 glioblastoma tumor growth by expression of insulin-like growth factor I receptor antisense mRNA”Cancer Immunol. Immunother., 1996, 42, 64-68.
Maher III, “Prospects for the Therapeutic Use of Antigene Oligonucleotides”,Cancer Investigation, 1996, 14(1), 66-82.
Resnicoff et al., “Rat Glioblastoma Cells Expressing an Antisense RNA to the Insulin-like Growth Factor-1 (IGF-1) Receptor are Nontumorigenic and Induce Regression of Wild-Type Tumors”,Cancer Research, 1994, 54, 2218-2222.
Pass et al., “Inhibition of Hamster Mesothelioma Tumorigenesis by an Antisense Expression Plasmid to the Insulin-like Growth Factor-1 Receptor”,Cancer Research, 1996, 56, 4044-4048.
Hua and Muschel, “Inhibition of Matrix Metalloproteinase 9 Expression by a Ribozyme Blocks Metastasis in a Rat Sarcoma Model System”,Cancer Research, 1996, 56, 5279-5284.
Brimacombe and Ching, “Nucleophilic Displacement Reactions in Carbohydrates”,Carbohydrate Research, 1968, 8, 82-88.
Boggemeyer et al., “Borrelia burgdorferiUpregulates the Adhesion Molecules E-selectin, P-selectin, ICAM-1 and VCAM-1 on Mouse Endothelioma Cells in vitro”,Cell Adhesion and Communication1994, 2, 145-157.
Kerr et al., “TGF-β1 Inhibition of Transin/Stromelysin Gene Expression is Mediated through a Fos Binding Sequence”,Cell, 1990, 61, 267-278.
Singh et al., “LNA (locked nucleic acids): synthesis and high-affinity nucleic acid recognition”,Chem. Commun., 1998, 4, 455-456.
Birkendal-Hansen, “Proteolytic remodeling of extracellular matrix”,Current Opinion in Cell Biology, 1995, 7, 728-735.
Leroith et al., “Molecular and Cellular Aspects of the Insulin-Like Growth Factor I Receptor”,Endocrine Reviews, 1995, 16, 143-163.
Kabanov at al., “A new class of antivirals: antisense oligonucleotides combined with a hydrophoic substituent effectively inhibit influenza virus reproduction and synthesis of virus-specific proteins in MDCK cells”,FEBS Lett., 1990, 259, 327-330.
Pierre Martin, “Ein Zugang zu 2′-O-Alkylribonucleosiden and Eigenschaften deren Oligonucleotide”,Helv. Chim. Acta, 1995, 78, 486-504.
Delisser at al., “Molecular and functional aspects of PECAM-1/CD31”,Immunology Today, 1994, 15, 490-495.
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