Bicyclomycin derivatives, compositions thereof and process of us

Details Bicyclomycin derivatives, compositions thereof and process of us Bicyclomycin derivatives, compositions thereof and process of us

1979-01-08

1982-03-30

Bond, Robert T.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

2602393B, A61K 31495, C07D49808

Patent

active

043224199

ABSTRACT:
Derivatives of 5-norbicyclomycin of the formula ##STR1## wherein R represents an unsubstituted or substituted monovalent hydrocarbon radical in which one, two or more carbon atoms can be replaced by heteroatoms, and X represents a bivalent group of the formula --O-- or --N(R')--, wherein R' has one of the meanings assigned to R, whilst R and R', if both have a meaning which is different from hydrogen, can also be linked to each other through a C--C bond or an oxygen, sulphur or nitrogen atom, and corresponding compounds, in which at least one hydroxyl group is protected, and salts of said compounds, provided they contain salt-forming groups, are useful as antibiotics, especially against Enterobacteriaceae, or as intermediates for the production of such antibiotics. They are obtained by condensing a corresponding 5-norbicyclomycin-5-one with a compound of the formula R--X--NH.sub.2 in which X and R have the above meaning.

REFERENCES:
patent: 3873526 (1975-03-01), Kamiya et al.
patent: 3923790 (1975-12-01), Imanaka et al.
patent: 4145344 (1979-03-01), Muller et al.
patent: 4215043 (1980-07-01), Kamiya et al.

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