Bicyclolactam derivative for improving cerebral function

Details Bicyclolactam derivative for improving cerebral function Bicyclolactam derivative for improving cerebral function

1992-08-05

1993-05-25

Dentz, Bernard

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514309, 514421, 540523, 546141, 548512, A61K 3140, C07D20946

Patent

active

052140393

ABSTRACT:
The present invention provides a bicyclolactam derivative which has the following formula and is useful as medicaments for treating senile dementia, i.e., as cerebral function improving agents and cerebral metabolism activators or anoxic brain damage protectives ##STR1## wherein R is benzoyl group which may be substituted with halogen atom, lower alkyl group, lower alkoxyl group, nitro group, cyano group or amino group; l is 1 or 2; m is 0 or 1; and n is 0, 1 or 2, provided that m and n are not 0 at the same time.

REFERENCES:
patent: 4621097 (1986-11-01), Butler et al.
Tetrahedron Letters, vol. 47, (1975), P. Y. Johnson et al., "Ring contraction reactions of 2-aminopyrazolidine-3-ones: A new synthesis of mono and bicyclo .beta.-Lactams", pp. 4089-4090.
Tetrahedron, vol. 27, No. 22, (1971), M. Langolis et al., "Recherches dans la serie des aryl-3 pyrrolidines-II Syntheses de produits apparentes a la mesembrine et a la critine", pp. 5641-5652.

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