Bicyclo heptane and bicyclo octane substituted inhibitors of cho

Details Bicyclo heptane and bicyclo octane substituted inhibitors of cho Bicyclo heptane and bicyclo octane substituted inhibitors of cho

1989-11-21

1990-09-18

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

514469, 514511, 514824, 560 59, 560118, 560120, 562466, 562500, 562502, A61K 3123, A61K 3120, C07C 69753, C07C 6112

Patent

active

049579401

ABSTRACT:
Certain bicyclo [2.2.1] heptane and bicyclo [2.2.2] octane substituted tetrahydro-2H-pyran-2-ones and the corresponding ring-opened acids derived therefrom are potent inhibitors of the enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase) and are useful as hypocholesterolemic and hypolipidemic agents.

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F. M. Singer, et al, Proc. Soc. Exper. Biol. Med. (1959), 102, 370.
F. H. Hulcher, Arch. Biochem. Biophys. 30 (1971) 146, 422.
Brown, et al, J. Chem. Soc. Perkin I, (1976), 1165.

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