Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2006-05-02
2006-05-02
Wilson, James O. (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S253060, C544S363000
Reexamination Certificate
active
07037913
ABSTRACT:
This invention provides compounds of Formula I having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with amido piperazine derivatives. These compounds possess unique antiviral activity, whether used alone or in combination with other antivirals, antiinfectives, immunomodulators or HIV entry inhibitors. More particularly, the present invention relates to the treatment of HIV and AIDS.A is selected from the group consisting of C1-6alkoxy, C1-6alkyl, C3-7cycloalkyl, phenyl, and heteroaryl; wherein said heteroaryl may be monocyclic or bicyclic and may be comprised of three to eleven atoms selected from the group consisting of C, N, NR9, O, and S, and wherein each ring of said phenyl and heteroaryl is optionally substituted with one to five same or different substituents selected from the group consisting of R19–R23;W is O or —NH;T isZ1is CR1or N;Z2is CR2or N;Z3is CR3or N;Z4is CR4or N;Z5is CR5or N;Z6is CR6or N;Z7is CR7or N;Z8is CR8or N.
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Kadow John F.
Meanwell Nicholas A.
Wallace Owen B.
Wang Tao
Yang Zhong
Bristol--Myers Squibb Company
DuBoff Samuel J.
Tucker Zachary C.
Wilson James O.
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