Bicyclicpyrimidones and their use to treat diseases

Details Bicyclicpyrimidones and their use to treat diseases Bicyclicpyrimidones and their use to treat diseases

2006-04-04

2006-04-04

McKenzie, Thomas C. (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

C544S256000

Reexamination Certificate

active

07022850

ABSTRACT:
The present invention is directed to dihydropyrimidones having formula I or II and methods of using them to induce mitotic arrest, thereby making them useful as anti-cancer agents and other diseases that can be treated by inducing mitotic arrest.

REFERENCES:
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patent: WO 00/39131 (2000-07-01), None
patent: WO 03/049527 (2003-06-01), None
patent: WO 2003049527 (2004-06-01), None
patent: WO 2004/78758 (2004-09-01), None
Qun Li; Hing L Sham, Expert Opinion on Therapeutic Patents, 2002, vol. 12, No. 11, pp. 1663-1702.
Paul J Coleman; Mark E Fraley, Expert Opinion on Therapeutic Patents, 2004, vol. 14, No. 12, pp. 1659-1667.
ClinicalTrials.gov “Identifier NCT00095628”, National Institutes of Health, [online] May 4, 2005, [retrieved on May 20, 2005]. Retrieved from the internet, <http://www.clinicaltrials.gov/ct/gui/show/NCT00095628>.
Draetta, G. and Pagano, M. in “Annual Reports in Medicinal Chemistry, vol. 31”, 1996, Academic Press, San Diego, p 241-246.

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