Bicyclic tetrahydroxypyrrolizidine

Details Bicyclic tetrahydroxypyrrolizidine Bicyclic tetrahydroxypyrrolizidine

1990-08-07

1991-11-26

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548423, 548453, 549214, A61K 3140, C07D48704, C07D49122, C07D49304

Patent

active

050682431

ABSTRACT:
Novel bicyclic tetrahydroxylated pyrrolizidines are disclosed which are inhibitors of glycosidase enzymes. A preferred inhibitor is (1S,2R,6R,7S)-1,2,6,7-tetrahydroxypyrrolizidine. It is synthesized from D-glycero-D-talo-heptono-1,4-lactone and utilizes the novel intermediate compounds, 7-O-tert-butyldiphenylsilyl-2,3:5,6-di-O-isopropylidene-D- glycero-D-talo-heptono-1,4-lactone and (1S,2R,6R,7S)-1,2:6,7-di-O-isopropylidene-1,2,6,7-tetrahydroxypyrrolizidin e, as follows:

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