Bicyclic sulfonamide derivatives

Details Bicyclic sulfonamide derivatives Bicyclic sulfonamide derivatives

1986-11-05

1989-08-29

Brust, Joseph Paul

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

546269, 546293, 549 23, 549 57, 549 90, 549397, 549463, 549546, 560 12, 560 13, 560118, 560120, 562500, 562502, C07C14372

Patent

active

048619132

ABSTRACT:
Bicyclic sulfonamido derivatives represented by the formula: ##STR1## wherein R.sub.1 is a hydrogen or lower alkyl; R.sub.2 is an alkyl, substituted or unsubstituted aryl, aralkyl or heterocycle; R.sub.3 is a hydrogen or methyl; X is an alkylene or alkenylene which may be substituted by a fluorine atom or atoms an may contain an oxygen, sulfur and/or phenylene in the chain; Y is straight or branched alkylene or alkenylene, oxygen, or sulfur; m is 0 or 1; and n is 0, 1 or 2, or their salt, said derivatives being useful as antithrombotic, anti-vasoconstricting, and anti-bronchoconstricting drugs.

REFERENCES:
patent: 3988362 (1976-10-01), Bernauer et al.
patent: 4389413 (1983-06-01), Hamanaka et al.
patent: 4458091 (1984-07-01), Jones et al.
patent: 4647585 (1987-03-01), Loots et al.
patent: 4654357 (1987-03-01), Nakane
Watanabe, et al.; C.A. 108: 111866e.

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