Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Reduced antigenicity – reduced ability to bind complement – or...
Patent
1979-02-28
1980-03-04
Phillips, Delbert R.
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Reduced antigenicity, reduced ability to bind complement, or...
2601125S, A61K 37100, C07C10352
Patent
active
041917545
ABSTRACT:
Bicyclic somatostatin analogs and pharmaceutically acceptable non-toxic acid addition salts thereof are prepared by a combination of the solid phase method and the solution method. These analogs have the property of inhibiting the release of insulin, glucagon and growth hormone in humans and animals. The compounds are particularly useful in the treatment of diabetes. Due to the bicyclic structure, these analogs are resistant to enzymatic metabolism and have a longer duration of activity.
REFERENCES:
patent: 4010260 (1977-03-01), Immer et al.
patent: 4115554 (1978-09-01), Ueber
patent: 4139526 (1979-02-01), Ueber
patent: 4140767 (1979-02-01), Ueber
Nutt Ruth F.
Veber Daniel F.
Hazel Blondel
Merck & Co. , Inc.
Phillips Delbert R.
Rose David L.
Westlake, Jr. Harry E.
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