Bicyclic pyrimidinones as coagulation cascade inhibitors

Details Bicyclic pyrimidinones as coagulation cascade inhibitors Bicyclic pyrimidinones as coagulation cascade inhibitors

2006-08-22

2006-08-22

Wilson, James O. (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S247000, C514S252140, C514S252190, C544S224000, C544S242000, C544S245000

Reexamination Certificate

active

07094783

ABSTRACT:
The present invention relates generally to compounds that inhibit serine proteases. In particular it is directed to novel amino-bicyclic pyrimidinone compounds of Formula (I):or a stereoisomer or pharmaceutically acceptable salt form thereof, which are useful as selective inhibitors of serine protease enzymes of the coagulation cascade; for example thrombin, factor Xa, factor XIa, factor IXa, and/or factor VIIa. In particular, it relates to compounds that are factor VIIa inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of using the same.

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