Bicyclic pyridines which are angiotensin II inhibitors

Details Bicyclic pyridines which are angiotensin II inhibitors Bicyclic pyridines which are angiotensin II inhibitors

1993-01-29

1995-05-30

Dentz, Bernard

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546121, A61K 31435, C07D47104

Patent

active

054201381

ABSTRACT:
The bicyclic derivatives of pyridines of the formula ##STR1## and their non-toxic, pharmaceutically acceptable salts and a process and intermediates for their preparation which compounds are inhibitors of angiotensin II effects, particularly a vasoconstrictor activity.

REFERENCES:
Thomas et al., J. Med. Chem., 35(5), pp. 877-885 (Mar. 1992).
Carini et al., J. Med. Chem., 34(8), pp. 2525-2547 (1991).
Chemical Abstract Service Chemical Abstracts vol. 64-No. 64 Feb. 14, 1966 Heterocyclic Compounds pp. 5069-5070.
American Chemical Society Journal of Medicinal Chemistry New Nonpeptide Angiotensin II Receptor Antagoinsts. Synthesis, Biological Properties, and Structure-Activity Relationships of 2-Alkyl Benzimidazole Derivatives Andrew P. Thomas, et al. Mar. 5, 1992, vol. 35, No. 5 pp. 877-885.
Central Research Laboratories, Kyorin Pharmaceutical Co. Ltd. Nogi-machi, Shimotsuga-gun, Tochigi 329-01, Japan Synthesis of 3-substituted Pyrazolo [1,5-.alpha.]pyridine Derivatives with Inhibitory Activity on Platelet Aggregation.II Katsuya Awano * Seigo Suzue Chem. Pham. Bull. 34(7) 2833-2839 (1986).
Department of Chemistry, E. Kardelj University of Ljubljana, 61000 Ljubljana, Yuigoslavia A New Approach for the Synthesis of Fused Imidazoles: The Synthesis of 3-Acyl-Substituted Imidaso[1,2-X]azines Simona Podergajs, et al Enigang: 26. Sep. 1983 pp. 263-265.
Chemical Abstracts vol. 81 Nov. 25, 1974, No. 21 Heterocycles Khim; Kiev, USSR. Kim. Geterotsol;/Soedin 1974, (8) 1146-7 (Russ). p. 421.
J. Org. Chem., vol. 41, No. 22, 1976 pp. 3549-3556 Imidazo[1,2-a]pyridines-Novel Substutition Reactions Elli S. Hand, et al.
Journal of Labelled Compounds and Radiopharmaceuticals vol. XXII, No. 7, pp. 735-743 Synthesis of Carbon-14 and Deuterium Labeled 3-Isobutyryl-2-Isopropylpyrazolo[1,5-a]Pyridine Yoshio Nagatsu, et al.
Universidad de Valladolid Departmento de Quimica Orgaganica Mar. 1988, Papers 203, The Reactions of 3-Unsubstituted Isoxazolium Salts with 1,2-Dinucleophiles. Synthesis of 4-Functionalized 3-Aminoisoxazoles and 3-Aminopyrazoles A. Alberola, et al.
Arzneimittel Forschung Drug Research 42(1), 1-96, Jan. 1992 Identification of Urinary Metabolites of 2-Methyl-3-(1,4,5,6-tetrahydronicotinoyl)pyrazolo[1,5-a]pyridine in Rat, Rabbit and Dog M. Komuro, et al, pp. 48-55.
Chemical Abstracts vol. 102, Apr. 29, 1985, No. 17 28-Heterocyles pp. 610-611.
Chemical Abstracts vol. 86, Jan. 3, 1977, No. 1 28-Heterocycles p. 475.
Chem. Pharm. Bull. 34(7) pp. 2828-2832 (1986) Synthesis of 3-Substituted Pyrazolo [1,5-.alpha.]pyridine Derivatives with Inihibitory Activity on Platelet Aggregation. I. K. Awano, et al.
Faculty of Pharmaceutical Sciences, Josai University, Keyakidai, Sakado, Saitama 350-02, Japan Ichiro Yokoe, et al Heterocycles, vol. 23, No. 6, 1985, pp. 1395-1397 1,3-Dipolar Cycloaddition Reaction of Chromones and Coumarin with Pyridinium Ylides.
Chemical Abstracts Pharmacology vol. 115, Aug. 19, 1991, No. 7, p. 784 C. Bianchi Pharmacology.
Chemical Abstracts vol. 112, Feb. 26, 1990, No. 9, p. 793 Heterocycles.
WO91/15479-Substituted Pyrazoles, Isoxazoles and Isothiazoles Allen, et al. Oct. 7, 1991.

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