Bicyclic prostaglandin analogs and method of synthesis

Details Bicyclic prostaglandin analogs and method of synthesis Bicyclic prostaglandin analogs and method of synthesis

1981-12-28

1984-03-13

Gerstl, Robert

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

560120, 560119, 568665, 568820, 564188, 562501, 548453, C07C17700

Patent

active

044369344

ABSTRACT:
New organopalladium reactions involving the addition of pi-allylpalladium compounds to strained bicyclic alkenes, and subsequent chain extension reactions employing the chemistry of organopalladium compounds are disclosed. By these techniques a large number of bicyclic prostaglandin analogs are prepared, which are useful as inhibitors of arachidonic acid induced platelet aggregation, and are specific inhibitors of thromboxane synthetase.

REFERENCES:
patent: 3759978 (1973-09-01), Lincoln
patent: 4073933 (1978-02-01), Shimomura

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