Bicyclic nucleosides, oligonucleotides, process for their prepar

Details Bicyclic nucleosides, oligonucleotides, process for their prepar Bicyclic nucleosides, oligonucleotides, process for their prepar

1992-10-13

1994-06-07

Robinson, Douglas W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 2713, 536 2714, 536 2721, 544245, 544264, 544265, 544268, 544269, C07H 1916, C07D47300

Patent

active

053190807

ABSTRACT:
Compounds of the formula I in the form of the racemates or enantiomers thereof, ##STR1## in which R.sub.1 and R.sub.2 independently of one another are hydrogen or a protective group, and B is a purine or pyrimidine radical or an analogue thereof, can be used as antiviral active ingredients or for the preparation of biologically active oligonucleotides.

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E. Uhlmann et al., Chem. Reviews, vol. 90, No. 4, (1990) 543-584.
V. Marquez et al., Medicinal Research, vol. 6, No. 1, (1986), 1-40.
Fissekis et al., "Synthesis of 5-Hydroxyalkylpyrimidines from Lactones. III. 5-Dihydroxycyclopentylpyrimidines", (1967) pp. 3595-3603.

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