Bicyclic lactams, processes for their use, and formulations cont

Details Bicyclic lactams, processes for their use, and formulations cont Bicyclic lactams, processes for their use, and formulations cont

1987-12-29

1989-03-07

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514213, 540523, 546157, 546158, C07D21522, A61K 3147

Patent

active

048107123

ABSTRACT:
Bicyclic lactams of the general formula I ##STR1## in which R.sup.1 and R.sup.2, which can be identical or different, denote a hydrogen atom or an alkyl group with 1 to 3 carbon atoms, R.sup.3 denotes an unsubstituted phenyl group or a phenyl group which is substituted by a halogen atom, one or two alkoxy groups, a methylenedioxo group or one or several hydroxyl groups, or denotes a pyridyl group, an indolyl group, a 1,2-benzisoxazolyl group which is optionally substituted by a halogen atom or the benzimidazol-2-one or 1,4-benzodioxane radical, R.sup.4 denotes a hydrogen atom or an alkyl group with 1 to 6 carbon atoms or a carbalkoxymethylen group, Z denotes a straight-chain, saturated or unsaturated alkylene group with 2 or 3 carbon atoms, which is optionally alkylated, X denotes an oxygen atom or a single bond and n denotes the number 1, 2 or 3, and their tautomeric forms and their salts and acid addition salts, block both the alpha and the beta receptors of the adrenergic system and are therefore suitable for the treatment of hypertension, circulatory disturbances, angina pectoris and coronary insufficiency.

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