Bicyclic lactam factor VIIa inhibitors useful as anticoagulants

Details Bicyclic lactam factor VIIa inhibitors useful as anticoagulants Bicyclic lactam factor VIIa inhibitors useful as anticoagulants

2007-12-17

2011-10-18

Wilson, James O (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C548S471000, C548S472000

Reexamination Certificate

active

08039506

ABSTRACT:
The present invention provides novel bicyclic lactams derivatives, and analogues thereof, of Formula (I):or a stereoisomer, tautomer, pharmaceutically acceptable salt, solvate, or prodrug thereof, wherein the variables A, B, C, W, Y, Z1, Z2, Z3, Z4, R8, and R9are as defined herein. These compounds are selective inhibitors of factor VIIa which can be used as medicaments.

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