Bicyclic ketones and their use in the field of perfumery

Organic compounds -- part of the class 532-570 series – Organic compounds – Oxygen containing

Utility Patent

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C568S849000

Utility Patent

active

06169212

ABSTRACT:

BRIEF SUMMARY OF THE INVENTION
The present invention relates to novel compounds useful in the field of perfumery. It concerns more particularly the compounds of formula
wherein the acetyl substituting group is either in position 2 or in position 3 of the ring, or any mixture of compounds of formula (I). Any further reference to a compound of formula (I) in the present application will designate either one or the other structural isomer or a mixture of both.
The compounds (I) possess odor properties which are very useful and appreciated. Therefore, they can be used for the preparation of perfumes, perfuming compositions and perfumed articles. These compounds can namely confer odor effects of the natural leather type.
BACKGROUND OF THE INVENTION
The compounds according to the present invention are novel.
The use in the field of perfumery of compounds having a structure close to that of the compounds (I) is known in the prior art. One can cite the patents U.S. Pat. No. 3,929,677 and EP 743 297 which disclose such compounds and discuss their odor properties.
DETAILED DESCRIPTION OF THE INVENTION
Surprisingly, we have now been able to establish that the compounds of formula (I) have a fragrance of a totally original character compared with the odor of known compounds. In fact, the odor of the compounds (I) constitutes an ensemble of woody, powdery-violet, ambergris, slightly marine seaweed type notes, accompanied with a very natural and really unexpected leather type connotation, reminiscent of the odor of fresh Suede leather. This last connotation really distinguishes the compounds of the present invention from the products of similar structure which are described in the prior art, thus conferring to said compounds a great value for their use in perfumery.
The compounds according to the present invention thus make it possible to confer, improve, enhance or modify the odor of consumer products, as well as perfuming bases or concentrates. In other words, they can impart to the latter their characteristic odor, as the case may be modifying and/or improving the original odor properties of the products and compositions in which they are incorporated. These products thus become more appealing to the consumer and have an enhanced odor impact.
The compounds of the invention can be used in fine perfumery, namely in perfumes, colognes, or after-shave lotions, as well as in other current uses in perfumery, namely to perfume soaps, shower or bath gels, hygiene or hair care products such as shampoos and also body or ambient air deodorants and cosmetic preparations.
The compounds (I) can also be used in applications such as liquid or solid detergents for textile treatment, fabric softeners, or yet detergent compositions or cleaning products for dishes or varied surfaces.
In these applications, said compounds (I) can be used alone as well as mixed with other perfuming ingredients, solvents or additives commonly used in perfumery. The nature and variety of these coingredients do not require a more detailed description here, which would not be exhaustive anyway. In fact, a person skilled in the art, having a general knowledge, is able to choose them according to the nature of the product that has to be perfumed and the olfactory effect sought.
These perfuming coingredients belong to varied chemical groups such as alcohols, aldehydes, ketones, esters, ethers, acetates, nitrites, terpenic hydrocarbons, heterocyclic nitrogen- or sulfur-containing compounds, as well as natural or synthetic essential oils. Many of these ingredients are listed in reference texts such as S. Arctander, Perfume and Flavor Chemicals, 1969, Montclair, N.J., USA, or more recent versions thereof, or in other similar books.
The proportions in which the compounds according to the invention can be incorporated in the different products mentioned above vary in a broad range of values. These values depend on the nature of the product that has to be perfumed and on the olfactory effect sought, as well as on the nature of the coingredients in a given composition when the compounds of the invention are used in admixture with perfuming coingredients, solvents or additives commonly used in the art.
For instance, concentrations from 5 to 10% by weight, or even 20% by weight, of the compounds of the invention, relative to the weight of the perfuming composition in which they are incorporated, can be used. Much lower concentrations than these can typically be used when these compounds are directly applied for perfuming some of the consumer products mentioned above.
The invention also relates to a process for the preparation of the compounds of formula (I). According to the process of the invention, an alcohol of formula
is subjected to a Diels Alder type reaction in the presence of a methylvinyl ketone, and this reaction is followed by dehydration and cyclisation. These three steps are effected in a one pot “cascade” reaction.
The alcohol of formula (II) is a novel compound and constitutes another object of the present invention. The latter can be obtained by a Grignard type reaction, starting from epoxymyrcene.
The whole synthesis can be described as follows:
The reaction conditions are described in more detail in an example presented hereafter.
The invention will now be described in greater detail in the following examples, wherein the temperatures are indicated in degrees centigrade and the abbreviations have the usual meaning in the art.


REFERENCES:
patent: 3265739 (1966-08-01), Blumenthal
patent: 3847993 (1974-11-01), Hall et al.
patent: 3929677 (1975-12-01), Hall et al.
patent: 4181683 (1980-01-01), Tsuji
patent: 5163453 (1992-11-01), Bachmann et al.
patent: 5707961 (1998-01-01), Bajgrowicz et al.
patent: 0 743 297 (1996-11-01), None
CA:114:121772 abs of EP379981, Aug. 1990.*

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