Bicyclic inhibitors of hormone sensitive lipase

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C514S322000, C514S359000, C546S210000, C548S257000

Reexamination Certificate

active

10685199

ABSTRACT:
Benzotriazoles of formula Iin which R1 to R8 have the abovementioned meanings and process for their preparation are described. The compounds show an inhibitory effect on hormone-sensitive lipase.

REFERENCES:
patent: 4255510 (1981-03-01), Simons et al.
patent: 4256881 (1981-03-01), Simons et al.
patent: 6221633 (2001-04-01), Ertl et al.
patent: 6221897 (2001-04-01), Baringhaus et al.
patent: 6245744 (2001-06-01), Baringhaus et al.
patent: 6342512 (2002-01-01), Kirsch et al.
patent: 0 462 884 (1991-12-01), None
patent: WO 97/26265 (1997-07-01), None
patent: WO 97/41097 (1997-11-01), None
patent: WO 98/08871 (1998-03-01), None
patent: WO 99/03861 (1999-01-01), None
patent: WO 99/15525 (1999-04-01), None
patent: WO 00/40569 (2000-07-01), None
patent: WO 00/63208 (2000-10-01), None
patent: WO 00/64876 (2000-11-01), None
patent: WO 00/64888 (2000-11-01), None
patent: WO 00/66585 (2000-11-01), None
patent: WO 00/71549 (2000-11-01), None
patent: WO 01/09111 (2001-02-01), None
patent: WO 01/17981 (2001-03-01), None
patent: WO 01/83451 (2001-11-01), None
patent: WO 01/85695 (2001-11-01), None
patent: WO 02/090355 (2002-11-01), None
patent: WO 03/020269 (2003-03-01), None
patent: WO 03/051842 (2003-06-01), None
Katritsky, Alan R. et al, “The Direct Carbamoylation of Organometallic Reagents with 1,2,3-Benzotriazole-1-carboxamides,” J. Chem. Research(S),1999, pp. 230-231.
Simons, Michael J. et al, “Development restrainer precursors for photographoic elements,” Research Disclosure Journal No. 19126, (1980). pp. 1-8.
Asakawa A et al., Cocaine-Amphetamine-Regulated Transcript Influences Energy Metabolism, Anxiety and Gastric Emptying in Mice, Hormone and Metabolic Research, 2001, 33(9), pp. 554-558.
Fredrikson G et al, Hormone-sensitive Lipase of Rat Adipose Tissue, J. Biol. Chem., 1981, vol. 256, No. 12, pp. 6311-6320.
Katritzky Alan R et al., A General Synthesis of Unsymmetrical Tetrasubstituted Ureas, Journal of Organic Chemistry, 1997, 62(12), 4155-4158.
Katritzky Alan R et al., The Direct Carbamoylation of Oranometallic Reagents with 12,3-Benzotriazole-1-carboxamides, J. Chem. Research (S), 1999, pp. 230-231.
Lee Daniel W et al., Leptin agonists as a potential approach to the treatment of obesity, Drugs of the Future, 2001, 26(9), pp. 873-881.
Nilsson S et al., Purification of Hormone-Sensitive Lipase by High-Performance Ion Exchange Chromatography, Anal. Biochem., 1986, vol. 158, pp. 399-407.
Okada Hiroshi et al., Synthesis and Antitumor Activities of Prodrugs of Benzoylphenylureas, Chem. Pharm. Bull. 1994, vol. 42(1), pp. 57-61.
Patkar S et al., Lipase inhibitors, Lipases their structure, biochemistry and application, Cambridge University Press, pp. 207-224.
Salvador Javier et al., Perspectives in the therapeutic use of leptin, Expert Opinion on Pharmacotherapy 2001, 2(10), 1615-1622.
Tornqvist H et al., Purification and Some Properties of a Monoacylglycerol-hydrolyzing Enzyme of Rat Adipose Tissue, J. Biol. Chem., 1976, vol. 251, No. 3, pp. 813-819.
Winzell Maria Sorhede et al., Pancreatic Beta-Cell Lipotoxicity Induced by Overexpression of Hormone-Sensitive Lipase, Diabetes, 2003, vol. 52, pp. 2057-2065.
Zunft H J F et al., Carob Pulp Preparation for Treatment of Hypercholesterolemia, Advances in Therapy, 2001, 18(5), pp. 230-236.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Bicyclic inhibitors of hormone sensitive lipase does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Bicyclic inhibitors of hormone sensitive lipase, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Bicyclic inhibitors of hormone sensitive lipase will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3721733

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.