Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1994-06-02
1996-04-30
Dees, Jose G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546 43, A01N 4342, A61K 3144
Patent
active
055125778
ABSTRACT:
The invention relates to the method of synthesis of bicyclic hexahydroaporphine compounds which may provide improved therapy for diseases characterized by an increase in intraocular pressure. More specifically, the present invention relates to the preparation of agents which may provide for improved treatment of patients with glaucoma or ocular hypertension. The present invention describes the intraocular pressure lowering capabilities of several of the bicyclic hexahydroaporphine structures.
REFERENCES:
Roche et al., Assessment of the in Vivo and in Vitro Opoid Activity of Bridged hexahydroaporphine and Isoquinoline Molecules, 1990, J. Med., Chem. pp. 245-248.
Ohia S. Edet
Roche Edward B.
Roche Victoria F.
Adler Benjamin Aaron
Creighton University
Dees Jos,e G.
Williams Rosalynd A.
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