Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2005-09-20
2009-06-16
Berch, Mark L (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C544S236000, C544S370000, C514S254060
Reexamination Certificate
active
07547698
ABSTRACT:
Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise, for example, administering to a mammal in need thereof a compound of formula (I): where x, y, J, K, L, M, W, V, R2, R3, R5, R5a, R6, R6a, R7, R7a, R8and R8aare defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
REFERENCES:
patent: 6627630 (2003-09-01), Kawano et al.
patent: 2005/0119251 (2005-06-01), Fu et al.
patent: 2007/0299081 (2007-12-01), Kamboj et al.
patent: 2008/0015230 (2008-01-01), Kamboj et al.
patent: WO 01/62954 (2001-08-01), None
patent: WO 02/26944 (2002-04-01), None
patent: WO 03/040125 (2003-05-01), None
patent: WO 03/066604 (2003-08-01), None
patent: WO 2004/035549 (2004-04-01), None
patent: WO 2005/011655 (2005-02-01), None
patent: WO 2005/011657 (2005-02-01), None
patent: WO 2006/034315 (2006-03-01), None
patent: WO 2006/034341 (2006-03-01), None
patent: WO 2006/034440 (2006-03-01), None
patent: WO 2006/034441 (2006-03-01), None
patent: WO 2006/034446 (2006-03-01), None
patent: WO 2006/101521 (2006-09-01), None
patent: WO 2007/130075 (2007-11-01), None
Dobrzyn, et al., Obesity Reviews 6, 169-174, 2005.
Giutiérrez-Juárez, et al., J. Clin. Invest., vol. 116, No. 6, Jun. 2006, pp. 1686-1695.
Warensjo, Obesity, Jul. 2007, 15(7):1732-40.
Park, et al., Am. Soc. For Nutritional Sciences, Jan. 10, 1997, pp. 566-573.
Miyazaki I, et al., J. Lipid Res., vol. 42, 2001, 1018-1024.
Miyazaki II, et al., J. Nutrition, 2001, 2260-2268.
Zheng, et al., Nature Genetics, vol. 23, Nov. 1999, 268-270.
Abuzar et al., “Synthesis of 2-carbalkoxyamino-5(6)-(1-substituted piperazin-4-yl/piperazin-4-ylcarbonyl)benzimidazoles and related compounds as potential anthelmintics,” Abstract Database CAPLUS on STN, Accession No. 1985:185052. See alsoPharmazie 39(11): 747-749, 1984.
Attie et al., “Relationship between stearoyl-CoA desaturase activity and plasma triglycerides in human and mouse hypertriglyceridemia,”Journal of Lipid Research 43: 1899-1907, 2002.
Cohen et al., “Role for Stearoyl-CoA Desaturase-1 in Leptin-Mediated Weight Loss,”Science 297: 240-243, Jul. 12, 2002.
de Antueno et al., “Relationship Between Mouse Liver Δ9 Desaturase Activity and Plasma Lipids,”Lipids 28(4): 285-290, 1993.
Dubey et al., “Synthesis and Anthelmintic Activity of 5(6)-(Benzimidazol-2-ylcarbamoyl) and (4-Substituted piperazin-1-yl)benzimidazoles,”J. Med. Chem. 28(11): 1748-1750, 1985.
Gooβen and Ghosh, “Palladium-Catalzyed Synthesis of Aryl Ketones from Boronic Acids and Carboxylic Acids Activated in situ by Pivalic Anhydride,”Eur. J. Org. Chem.: 3254-3267, 2002.
Jeffcoat and James,New Comprehensive Biochemistry vol. 7: Fatty Acid Metabolism and Its Regulation,Elsevier Science Publishers B.V., Amsterdam, The Netherlands, Chapter 4, “The regulation of desaturation and elongation of fatty acids in mammals,” 85-112, 1984.
Ntambi et al., “Loss of stearoyl-CoA desaturase-1 function protects mice against adiposity,”Proc. Natl. Acad. Sci. USA 99(17): 11482-11486, Aug. 20, 2002.
Ravina et al., “Synthesis and potential anthelmintic activity of methyl 5-(4-salicyloylpiperazin-1-yl)benzimidazole-2-carbamates,” Abstract Database CAPLUS on STN, Accession No. 1994:54512. See alsoArzneimittel-Forschung 43(6): 689-694, 1993.
Vice et al., “Concise Formation of 4-Benzyl Piperidines and Related Derivatives Using a Suzuki Protocol,”J. Org. Chem. 66:2487-2492, 2001.
U.S. Appl. No. 10/326,210, filed Dec. 20, 2002, Mark P. Gray-Keller et al., entitled “Pyridylpiperazines and Aminonicotinamides and Their Use as Therapeutic Agents”.
Chakka Nagasree
Fu Jian-min
Hou Duanjie
Kamboj Rajender
Kodumuru Vishnumurthy
Berch Mark L
Jaisle Cecilia M
Seed IP Law Group PLLC
Xenon Pharmaceuticals Inc.
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