Bicyclic heteroaryl inhibitors of PDE4

Details Bicyclic heteroaryl inhibitors of PDE4 Bicyclic heteroaryl inhibitors of PDE4

2007-07-06

2010-06-29

Andres, Janet L. (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C544S093000, C549S269000, C549S270000, C549S271000

Reexamination Certificate

active

07745646

ABSTRACT:
The present invention relates to compounds and methods which may be useful as inhibitors of phosphodiesterase 4 (PDE4) for the treatment or prevention of inflammatory diseases and other diseases involving elevated levels of cytokines and proinflammatory mediators.

REFERENCES:
patent: 5412104 (1995-05-01), Afonso
patent: 5563280 (1996-10-01), Alvarado et al.
patent: 5681968 (1997-10-01), Alvarado
patent: 6034121 (2000-03-01), O'Mahony
patent: 2003/0096254 (2003-05-01), Reed et al.
patent: 2004/0180950 (2004-09-01), Wu
patent: 2005/0137231 (2005-06-01), McKie et al.
patent: 2006/0148834 (2006-07-01), Xu
patent: 2006/0223783 (2006-10-01), Xu
patent: 2008/0027099 (2008-01-01), Govek et al.
patent: 655242 (1994-10-01), None
patent: 2711992 (1995-05-01), None
patent: 9412488 (1994-06-01), None
patent: 9424118 (1994-10-01), None
patent: 03097628 (2003-11-01), None
patent: WO 2006083692 (2006-08-01), None
patent: 2006098624 (2006-09-01), None
patent: WO 2008006052 (2008-01-01), None
CA 143:161248 (2004).
CA 19:72432.
Desai, Devki; Synthesis of Aminomethyl Coumarin Derivatives and TheirAantibacterial Activity; Indian Journal of Heterocyclic Chemistry (2004), 13(4), 355-360. Department of Chemistry, Faculty of Science, M.S. University of Baroda, Vadodara, 390 002, India.
Xu, Song; Synthesis of Substituted 4-styrylcoumarin and Their Antitumor Activities; Yaoxue Xuebao (2001), 36(4), 269-273. Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, Peop. Rep. China.
Khaikin, M.S.; Ultraviolet spectra of some 6,7- and 7,8-dihydroxycoumarins; Zhumal Prikladnoi Spektroskopii (1968), 8(6), 1063-6. USSR.
Libermann, D.; Antithyroid substances. II. Ethyl—phenylacetoacetate and 6-benzyl-2-thiouracil; Bull. Soc. Chim. France (1950), 1217-22.
Kotwani, N.G.; Pechmann condensation of phenols with ethyl -phenylacetoacetate; Journal of the University of Bombay, Science: Physical Sciences, Mathematics, Biological Sciences and Medicine (1942), 10(Pt. 5), 143-6.
Mahal, Harbhaja S.; Some 4-Styrylcoumarins; Journal of the Chemical Society (1933) p. 616-617.
Labey, R, The action of acids of the esculetol group on the oxidation of adrenaline, Annales Pharmaceutiques Francaises, 1949, 439-441, 7.
Mehta, D.H., et al, Pechmann reaction: coumarins from 2-ethylquinol and 4-ehtylpyrogallol, Journal of the Indian Chemical Society, 1956, 135-139, 33, (Abstract).
Loewenthal, H.J.E., Synthesis in the Colchicine Series. I. Products from the Stobbe condensation of methyl 4- (2,3,4-trimethoxybenzoyl)butyrate with dimethyl succinate, J. Chem. Soc., 1953, 3962-3968.
Ponniah, L, et al, the synthesis of coumarinyl styrenes, Univ. Delhi Proceedings - Indian Academy of Sciences, Section A, 1953, 534-543, 37A.
Dey, Biman B, A Study in the coumarin condensation, J Chem Soc Trans, 1915, 1606-1651, 107.
Chilin, A, et al, Synthesis of benzopsoralenquinone derivatives, Synthesis, 1995, 1190-1194, 9.
Mahal, Harbhajan S, et al, Some 4-syrylcoumarins, Journal of the Chemical Society, 1933, 516-517.

Affiliated with

Also associated with

Rating

Bicyclic heteroaryl inhibitors of PDE4 does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Bicyclic heteroaryl inhibitors of PDE4, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Bicyclic heteroaryl inhibitors of PDE4 will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4191381