Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1982-03-10
1984-07-31
Gerstl, Robert
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
424250, 424251, 424263, 424268, 424270, 424272, 424273R, 544212, 544296, 544331, 544357, 544405, 546276, 546277, 546278, 546281, 548128, 548131, 548202, 548235, 548255, 548269, 548336, C07D40106, C07D41306, A61K 31505
Patent
active
044630050
ABSTRACT:
The invention relates to bicyclic derivatives which are histamine H-2 antagonists and which inhibit gastric acid secretion. According to the invention there is provided a guanidine derivative of the formula I: ##STR1## in which R.sup.1 and R.sup.2, same or different, are hydrogen or 1-10C alkyl, 3-8C cycloalkyl or 4-14C cycloalkylalkyl, each alkyl, cycloalkyl or cycloalkylalkyl optionally carrying one or more F, Cl or Br atoms, provided that one of R.sup.1 and R.sup.2 is halogen substituted, or R.sup.2 is hydrogen and R.sup.1 is R.sup.3 -E-W in which W is 2-6C alkylene optionally substituted by 1 or 2 1-4C alkyls, E is O, S, SO, SO.sub.2 or NR.sup.4 in which R.sup.4 is H or 1-6C alkyl, R.sup.3 is H or 1-6C alkyl optionally substituted by 1 or 2 1-4C alkyls, or R.sup.3 and R.sup.4 are joined to form a pyrrolidine, piperidine, morpholine, piperazine or N-methylpiperazine ring, or R.sup.2 is H and R.sup.1 is H, 1-10C alkyl, 3-8C cycloalkyl, 4-14C cycloalkylalkyl, 3-6C alkenyl, 3-6C alkynyl, 1-6C alkanoyl, 6-10C aryl, 7-11C aralkyl or 7-11C aroyl; ring X is a heterocyclic ring as defined in the specification; A is phenylene or 5-7C cycloalkylene, or a 1-8 C alkylene into which is optionally inserted one or two groups; ring Y is a heterocyclic ring described in the specification: and the pharmaceutically-acceptable acid-addition salts thereof. Manufacturing processes and pharmaceutical compositions are also described.
REFERENCES:
patent: 4242350 (1980-12-01), Yellin et al.
patent: 4242351 (1980-12-01), Yellin et al.
patent: 4302464 (1981-11-01), LaMattina et al.
patent: 4315009 (1982-02-01), Jones et al.
patent: 4342765 (1982-08-01), Jones et al.
patent: 4362728 (1982-12-01), Yellin
Jones Derrick F.
Oldham Keith
Gerstl Robert
Imperial Chemical Industries plc
LandOfFree
Bicyclic guanidines does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Bicyclic guanidines, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Bicyclic guanidines will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-185409