Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...
Patent
1992-06-17
1995-02-28
Rotman, Alan L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Phosphorus containing other than solely as part of an...
514 89, 540476, 546 23, C07F 965, A61K 31675
Patent
active
053937465
ABSTRACT:
The present invention relates to novel compounds having nitrogen-containing, saturated bicyclic cylopentane-fused rings which are geminally disubstituted with phosphonate groups. Most preferred compounds of the present invention have the general structure: ##STR1## The present invention further relates to pharmaceutical compositions containing these novel compounds. Finally, this invention relates to methods for treating or preventing diseases characterized by abnormal calcium and phosphate metabolism by utilizing a compound or pharmaceutical composition of the present invention.
REFERENCES:
patent: 3553314 (1971-01-01), Francis
patent: 3683080 (1972-08-01), Francis
patent: 3846420 (1974-11-01), Wollmann et al.
patent: 3899496 (1975-08-01), Schindler et al.
patent: 3941772 (1976-03-01), Ploger et al.
patent: 3957160 (1976-05-01), Ploger et al.
patent: 3960888 (1976-06-01), Ploger et al.
patent: 3979385 (1976-09-01), Wollmann et al.
patent: 3988443 (1976-10-01), Ploger et al.
patent: 4034086 (1977-07-01), Ploger et al.
patent: 4086334 (1978-04-01), Schmidt-Dunker et al.
patent: 4104366 (1978-08-01), Schmidt-Dunker et al.
patent: 4117090 (1978-09-01), Ploger
patent: 4230700 (1980-10-01), Francis
patent: 4267108 (1981-05-01), Blum et al.
patent: 4687767 (1987-08-01), Bosies et al.
patent: 4687768 (1987-08-01), Benedict et al.
patent: 4719203 (1988-01-01), Bosies et al.
patent: 4868164 (1989-09-01), Ebetino et al.
patent: 5137880 (1992-08-01), Ebetino et al.
Unterspann, 1 European J. Nuclear Medicine 151 (1976).
E. Landeck et al., 30 Stomatol DDR 169 (1980).
Izv. Akad. Nauk SSSR. Ser. Khim (12)2802 (1983) (Chemical Abstract 100:12144).
Buckingham Kent W.
Ebetino Frank H.
McOsker Jocelyn E.
Clark Karen F.
P&G Pharmaceuticals, Inc.
Roof Carl J.
Rotman Alan L.
Suter David L.
LandOfFree
Bicyclic diphosphonate compounds, pharmaceutical compositions, a does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Bicyclic diphosphonate compounds, pharmaceutical compositions, a, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Bicyclic diphosphonate compounds, pharmaceutical compositions, a will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-848597